- BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
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Kim DH, Do MS
- KMID: 2155394
- Exp Mol Med.
- 2015 Jan;47(1):e129.
- doi: 10.1038/emm.2014.98
Obesity is recognized as a chronic low-grade inflammatory state due to adipose tissue expansion being accompanied by an increase in the production of proinflammatory adipokines. Our group is the first... -
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- CD36, a scavenger receptor implicated in atherosclerosis
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Park YM
- KMID: 2155364
- Exp Mol Med.
- 2014 Jun;46(6):e99.
- doi: 10.1038/emm.2014.38
CD36 is a membrane glycoprotein that is present on various types of cells, including monocytes, macrophages, microvascular endothelial cells, adipocytes and platelets. Macrophage CD36 participates in atherosclerotic arterial lesion formation... -
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- Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes
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Tsukamoto , Takeuchi M, Kawaguchi , Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C
- KMID: 2155354
- Exp Mol Med.
- 2014 Apr;46(4):e89.
- doi: 10.1038/emm.2013.161
LR11, also known as SorLA or SORL1, is a type-I membrane protein from which a large extracellular part, soluble LR11 (sLR11), is released by proteolytic shedding on cleavage with a... -
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- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
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Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
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- Toll-like receptor 9-mediated inhibition of apoptosis occurs through suppression of FoxO3a activity and induction of FLIP expression
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Lim EJ, Park DW, Lee JG, Lee CH, Bae YS, Hwang YC, Jeong JW, Chin BR, Baek SH
- KMID: 964666
- Exp Mol Med.
- 2010 Oct;42(10):712-720.
- doi: 10.3858/emm.2010.42.10.070
Synthetic oligodeoxynucleotides (ODN) with a CpG-motif are recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Stimulation of macrophages with TLR9 agonist prevented apoptosis induced by serum... -
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- TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions
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Nam EH, Park SR, Kim PH
- KMID: 983953
- Exp Mol Med.
- 2010 Sep;42(9):606-613.
- doi: 10.3858/emm.2010.42.9.059
Angiogenesis is a multi-step process that involves the activation, proliferation, and migration of endothelial cells. We have recently shown that TGF-beta1 can induce mouse macrophages to produce VEGF, a potent... -
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- Increased expression of osteopontin in the spinal cords of Lewis rats with experimental autoimmune neuritis
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Moon C, Shin T
- KMID: 1093622
- J Vet Sci.
- 2004 Dec;5(4):289-293.
To investigate the pattern of expression of osteopontin (OPN) in tissues of the central nervous system (CNS) responding to peripheral immunological stimulation, the expression of OPN was studied in the... -
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- The role of nitric oxide in the immune response of tuberculosis
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Kwon OJ
- KMID: 645106
- J Korean Med Sci.
- 1997 Dec;12(6):481-487.
- doi: 10.3346/jkms.1997.12.6.481
Nitric oxide (NO) formed by the action of inducible form of nitric oxide synthase (iNOS), reacts with oxygen radical forming reactive nitrogen intermediate (RNI). NO and related RNI have... -
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- Production of tumor necrosis factor-alpha by alveolar macrophages from patients with pulmonary tuberculosis
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Kim SJ, Kim HI, Lee YH, Kim SK
- KMID: 1421514
- J Korean Med Sci.
- 1991 Mar;6(1):45-53.
- doi: 10.3346/jkms.1991.6.1.45
In order to ascertain the role of TNF-alpha in pulmonary tuberculosis, we determined the TNF-alpha productivity of alveolar macrophages(AMs) obtained by bronchoalveolar lavage(BAL), along with the level of TNF-alpha in... -
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