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Development of thymic lymphomas in mice disrupted of Brca2 allele in the thymus

Park PG, Lee H

Germ-line mutations in BRCA2 predispose to early-onset cancer. Homozygous mutant mouse, which has Brca2 truncated in exon 11 exhibit paradoxic occurrence of growth retardation and development of thymic lymphomas. However,...
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Immunoglobulin and T-cell receptor gene rearrangement analysis in malignant lymphoid neoplasms

Park CK, Kim CW, Kim IS, Lee JD

Gene rearrangement analysis using Southern-blot hybridization technique is a standard method for evaluating clonal receptor gene rearrangement. Both clonality and lineage can be identified in lymphoid neoplasms by the demonstration...
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