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Telomerase is strongly activated in hepatocellular carcinoma but not in chronic hepatitis and cirrhosis

Park YM, Choi JY, Byun BH, Cho CH, Kim HS, Kim BS

  • KMID: 754985
  • Exp Mol Med.
  • 1998 Mar;30(1):35-40.
Telomerase is highly activated in human immortal cell lines and tumor tissues, whereas it is not activated in primary cell strains and many tumor-adjacent tissues. It is suggested that telomerase activation is...
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Anti-tumor mechanisms and regulation of survivin by selective cyclooxygenase-2 inhibitor

Jang JW

No abstract available.
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Hepatitis C virus genotypes in Korea and their relationship to clinical outcome in type C chronic liver diseases

Han CJ, Lee HS, Kim HS, Choe JH, Kim CY

  • KMID: 1038875
  • Korean J Intern Med.
  • 1997 Jan;12(1):21-27.
OBJECTIVES: The relationship between HCV genotype and the development of more serious liver disease has not been clearly established. This study was to investigate the distribution pattern of HCV genotypes...
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Prevalence of viral hepatitis markers in Korean patients with hepatocellular carcinoma

Huh K, Choi SY, Whang YS, Lee DS

The positive rates of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV) were analyzed according to year, sex, age, and serum ALT levels in 1,370...
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Newer treatments for advanced hepatocellular carcinoma

Song MJ, Bae SH

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The only curative treatment modalities for HCC are surgery, percutaneous ablation, and liver transplantation. Unfortunately, the majority of patients...
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Down-regulation of survivin in growth inhibition of hepatoma cells induced by a selective cyclooxygenase-2 inhibitor

Song IH, Kim DW, Shin KC, Shin HD, Yun SY, Kim SB, Shin JE, Kim HJ, Kim EY

BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) inhibitors reportedly inhibit the growth of hepatocellular carcinoma (HCC) via caspase-dependent or caspase-independent apoptosis, which is due to COX-2 being associated with hepatocarcinogenesis. Survivin is highly...
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Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A2 and 12-PGJ2.

Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim HS, Shim JY, Kim JW, Lee JH, Kim IK

  • KMID: 1380233
  • Exp Mol Med.
  • 2002 Jul;34(3):243-249.
We reported earlier that expression of Sox-4 was found to be elevated during prostaglandin (PG) A2 and delta(12)-PGJ(12) induced apoptosis in human hepatocarcinoma Hep3B cells. In this study, the role...
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