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Relevance of Ultrastructural Alterations of Intercellular Junction Morphology in Inflamed Human Esophagus

Liu CC, Lee JW, Liu TT, Yi CH, Chen CL

  • KMID: 2326232
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):324-331.
BACKGROUND/AIMS: Detailed characterization of the ultrastructural morphology of intercellular space in gastroesophageal reflux disease has not been fully studied. We aimed to investigate whether subtle alteration in intercellular space structure...
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Atypical Symptoms in Patients With Gastroesophageal Reflux Disease

Yi CH, Liu TT, Chen CL

  • KMID: 2325923
  • J Neurogastroenterol Motil.
  • 2012 Jul;18(3):278-283.
BACKGROUND/AIMS: Atypical symptoms are common in gastroesophageal reflux disease (GERD). Patients with non-erosive reflux disease (NERD) and erosive reflux disease (ERD) exhibit different clinical characteristics and responses to acid suppression...
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Impact of Sleep Dysfunction on Anorectal Motility in Healthy Humans

Liu TT, Yi CH, Chen CL, Orr WC

  • KMID: 2326213
  • J Neurogastroenterol Motil.
  • 2011 Apr;17(2):180-184.
BACKGROUND/AIMS: Sleep dysfunction is associated with altered gastrointestinal function and subsequently exacerbations of gastrointestinal problems. We aimed to investigate whether sleep dysfunction would influence anorectal motility as determined by anorectal...
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Esophageal Bolus Domain Pressure and Peristalsis Associated With Experimental Induction of Esophagogastric Junction Outflow Obstruction

Lei WY, Omari T, Liu TT, Wong MW, Hung JS, Yi CH, Liang SW, Cock C, Chen CL

  • KMID: 2523784
  • J Neurogastroenterol Motil.
  • 2022 Jan;28(1):62-68.
  • doi: 10.5056/jnm20224
Background/Aims Intrabolus pressures are important for esophageal bolus transport and may detect obstructed bolus flow. This study measured the effect esophageal outflow obstruction experimentally induce by a leg-lift protocol. Methods Twenty-five gastroesophageal reflux...
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Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility

Lei WY, Liang SW, Omari T, Chang WC, Wong MW, Hung JS, Yi CH, Liu TT, Lin L, Gyawali CP, Chen CL

  • KMID: 2534318
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):589-598.
  • doi: 10.5056/jnm21189
Background/Aims Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during...
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