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Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Zhu Z, Xie Y, Guan W, Gao Y, Xia S, Shi X, Zheng J

BACKGROUND: The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine...
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Influence of Vasoactive Substances on the Regulation of Cardiac ATP-Sensitive Potassium Channel Activity

Kim JH, Ju JM, Piao LH, Kim YY, Jeong HS, Park HW, Jeong DH, Lee SR, Yoon NS, Kim KH, Hong YJ, Kim JH, Kim W, Ahn YK, Jeong MH, Cho JG, Park JC, Kang JC

BACKGROUND AND OBJECTIVES: It has been known that various vasoactive agents are involved in the regulation of cardiac function through the modification of the K+ channel activities, including the ATP-sensitive...
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MUC2/5AC Expression and Mucin Secretion through Leukotriene Receptor in Human Airway Epithelial Cells

Kim YD, Lee JE, Bai CH, Seo YJ, Ye SB, Song SY

  • KMID: 2276273
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Nov;47(11):1115-1119.
BACKGROUND AND OBJECTIVES: Mucin gene expression and mucin production are highly increased during inflammatory airway disorders such as, asthma, chronic bronchitis and sinusitis. Cytokines, lipopolysaccharides and other inflammatory mediators are...
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The Effects of Leukotriene Receptor Antagonist on Nasal Mucous Membrane in Allergic Model of Guinea Pigs

Yu MS, Lee JH, Park JK, Lee JD, Kim DW, Lee BD, Chang HS, Cho JS

  • KMID: 2115454
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Dec;46(12):1028-1034.
BACKGROUND AND OBJECTIVES: The leukotriene (LT) receptor antagonist is subject to an on-going study of allergic rhinitis, nasal polyposis and chronic paranasal sinusitis. This study was designed to evaluate the...
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The Difference between the Concentrations of Arachidonic Acid Metabolites in the Cholesterol Granuloma and Granulation Tissues in Chronic Otitis Media

Jang YJ, Kim HG, Oh JK, Rhee CK

  • KMID: 1923255
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 May;44(5):466-469.
BACKGROUND AND OBJECTIVES: Both the granulation tissue and cholesterol granuloma can erode the surrounding bone and ossicles. However, the etiology of bone resorption in the granulation tissue and cholesterol granuloma...
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Effect of Mahuangbujaseshintang and Soshihotang in animal model of allergic rhinitis

Hong NP, Cho JS, Jin YW, Hong SU

  • KMID: 1850959
  • J Asthma Allergy Clin Immunol.
  • 2000 Aug;20(4):619-626.
BACKGROUND AND OBJECTIVE: Mahuangbujaseshintang (MBST) and soshihotang (SST) have been used for treatment of chronic disease of respiratory tract. It is necessary to clarify the mechanism of anti-allergic effects and...
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Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • KMID: 2071837
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
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Mast Cells and Allergic Rhinitis

Cho JS

  • KMID: 2297727
  • J Rhinol.
  • 1998 Nov;5(2):85-91.
That mast cells play a role in acute allergic inflammation by releasing various inflammatory mediators, including histamine, leukotrienes (LT), such as LTC4 and LTD4, and prostaglandins (PG), such as PGD2,...
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Inhibitory Effect of Rebamipide on Helicobacter pylori Induced Release of Leukotriene D4

Lee JJ, Han BG, Kim MN, Chung MH

  • KMID: 1943438
  • J Korean Soc Microbiol.
  • 1997 Dec;32(6):653-658.
It has been implicated that leukotrienes play roles in the pathogenesis of gastritis and gastric ulceration associated with Helicobacter pylori (H. pylori). Rebamipide is being used as an antiulcer drug...
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The inhibitory effect of eupatilin on Helicobacter pylori-induced release of leukotriene D4 in the human neutrophils and gastric mucosal cells

Lee JJ, Han BG, Kim MN, Chung MH

  • KMID: 1554768
  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):573-580.
In this report, the inhibitory action of eupatilin was investigated by using leukotriene D4 in the human neutrophils and Kato III cells (Gastric adenoma cells as a substitute for gastric mucosal cells) stimulated...
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Effects of Leukotriene D4 on Ultrastructure of Nasal Mucous Membrane in Guinea Pigs

Cho SH, Cho JS, Jang DY, Cha CI, Lee SM

  • KMID: 2274279
  • Korean J Otolaryngol-Head Neck Surg.
  • 1997 Jan;40(1):91-97.
The aim of this study was to evaluate effects of leukotriene D4(LTD4) on the nasal airway. Fifteen guinea pigs were divided into two groups;10 for experimental group and 5 for...
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Effects of Azelastine in the treatment of Patients with Chronic Bronchial Asthma

Cho SH, Kim WK, Yoon HJ, Min KU, Kim YY

  • KMID: 1970664
  • Allergy.
  • 1994 Mar;14(1):42-47.
Azelastine is an orally effective and long acting antiallergic agent with bronchodilating effect which has recently been developed for the treatment of bronchial asthma. Its properties have been described as...
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