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Plasma LTE₄/PGF₂α Ratio and Blood Eosinophil Count Are Increased in Elderly Asthmatics With Previous Asthma Exacerbation

Ban GY, Ye YM, Kim SH, Hur GY, Kim JH, Shim JJ, Cho K, Cho JY, Park HS, PRANA group

The tools for asthma control assessment recommended by the current guideline are cognitive function- and effort-dependent, which is substantially impaired in the elderly. The aim of this study is to...
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Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children

Kwak BO, Park YM

PURPOSE: Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (EBC) could be predictive of inflammatory status and effectiveness of treatment in allergic disease. The aim...
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Asthma Severity and the Controller Prescription in Children at 12 Tertiary Hospitals

Suh DI, Yang HJ, Kim BS, Shin YH, Lee SY, Park G, Kim WK, Kim HB, Baek H, Kim JK, Kim JT, Lim DH, Asthma Study Group for Preschool Children

PURPOSE: Guidelines need to be tailored to where they are applied. We aimed to describe the distinctive asthma severity profile and the pattern of controller prescription in Korean children. METHODS: Twelve...
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Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Zhu Z, Xie Y, Guan W, Gao Y, Xia S, Shi X, Zheng J

BACKGROUND: The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine...
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A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma

Tavasoli A, Sayyahfar , Behnam B

Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or...
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A Case of Pranlukast-Induced Anaphylactic Shock

Kim S, Lee JM

Leukotriene receptor antagonists, which are generally considered safe with a few adverse drug reactions, are increasingly used in the treatment of various allergic diseases, including asthma and allergic rhinitis. Although...
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Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells

Jeong KT, Lee E, Park NY, Kim SG, Park HH, Lee J, Lee YJ, Lee E

Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse...
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The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia

Kim SB, Lee JH, Lee J, Shin SH, Eun HS, Lee SM, Sohn JA, Kim HS, Choi BM, Park MS, Park KI, Namgung R, Park MS

PURPOSE: The purpose of this study was to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonarydysplasia (BPD). METHODS: The Interventional study was designed as a multicenter,...
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Addition of Montelukast to Low-Dose Inhaled Corticosteroid Leads to Fewer Exacerbations in Older Patients Than Medium-Dose Inhaled Corticosteroid Monotherapy

Ye YM, Kim SH, Hur GY, Kim JH, Park JW, Shim JJ, Jung KS, Lee HY, Park HS, PRANA Group

PURPOSE: There have been few reports regarding the efficacy of antiasthmatics in older patients. To compare the efficacy of the addition of montelukast to low-dose inhaled budesonide (MON-400BUD) versus increasing...
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The role of leukotriene modifier in pediatric allergic disease

Choi BS, Sohn MH, Kim KE

Leukotriene (LT) modifiers are composed of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. LTs, C4, D4, and E4 are collectively termed cysteinyl LTs and best are the characterized receptors for cysLTs...
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Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes

Park SJ, Saleem MA, Nam JA, Ha TS, Shin JI

PURPOSE: The aim of this study was to investigate whether pathologic changes in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experimental minimal-change nephrotic syndrome (MCNS) model and...
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Increased inflammatory mediator in exhaled breath condensate from asthmatic children

Han YK, Park JY, Kim MN, Kim YH, Park HB, Kim MJ, Lee KE, Lee HS, Heo WI, Hong JY, Kim KW, Sohn MH, Kim KE

PURPOSE: There has recently been increasing interest in the use of exhaled breath condensate (EBC) as a simple noninvasive means for understanding the physiology of asthma. The aim of this...
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Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts

Kanaoka Y, Boyce JA

Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties...
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Integrating Evidence for Managing Asthma in Patients Who Smoke

Price D, Bjermer L, Popov TA, Chisholm A

Cigarette smoking among asthma patients is associated with worsening symptoms and accelerated decline in lung function. Smoking asthma is also characterized by increased levels of neutrophils and macrophages, and greater...
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Molecular Genetic Mechanisms of Chronic Urticaria

Losol P, Yoo HS, Park HS

Chronic urticaria (CU) is a common allergic skin disease that requires long-term pharmacological treatment. Some patients with severe CU suffer a poor quality of life. Although the pathogenic mechanisms of...
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Curcumin Inhibits the Activation of Immunoglobulin E-Mediated Mast Cells and Passive Systemic Anaphylaxis in Mice by Reducing Serum Eicosanoid and Histamine Levels

Li X, Lu Y, Jin Y, Son JK, Lee SH, Chang HW

  • KMID: 2048327
  • Biomol Ther.
  • 2014 Jan;22(1):27-34.
Curcumin is naturally occurring polyphenolic compound found in turmeric and has many pharmacological activities. The present study was undertaken to evaluate anti-allergic inflammatory activity of curcumin, and to investigate its...
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Therapeutic Effect of Combination Treatment of Antihistamine and Montelukast in Allergic Rhinitis

Son HR, Lee KI, Chung YJ, Mo JH

  • KMID: 2297561
  • J Rhinol.
  • 2013 May;20(1):20-25.
BACKGROUND: Montelukast is a type 1 cysteinyl-leukotrienes receptor antagonist that has been widely used in allergic disease. However, the effect of combination of leukotriene receptor antagonist and antihistamine is controversial....
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Ratio of Leukotriene E4 to Exhaled Nitric Oxide and the Therapeutic Response in Children With Exercise-Induced Bronchoconstriction

Baek HS, Cho J, Kim JH, Oh JW, Lee HB

PURPOSE: This study assessed the association between the ratio of leukotriene E4 (LTE4) to fractional exhaled nitric oxide (FENO) in the response of children with exercise-induced bronchoconstriction (EIB) enrolled in...
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Leukotrienes and Allergic Inflammation

  • KMID: 1969527
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Jun;32(2):67-72.
Leukotrienes (LTs) are important lipid mediators involved in allergic inflammation. The LT pathway is relatively steroid-resistant, which suggests the possibility that its blockade by alternative means may facilitate asthma management....
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The Effects of Anti-histamine and Leukotriene Receptor Antagonist Against Ischemia-Reperfusion Injury

Cho HI, Chang H, Kim SW

  • KMID: 2321174
  • J Korean Soc Microsurg.
  • 2012 May;21(1):61-67.
PURPOSE: The purpose of this study was to investigate the role of mast cells and their product, histamine and leukotriene in ischemia-reperfusion injury. METHODS: Forty Sprague-Dawley rats were divided into four...
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