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Causes of Positive Pretransplant Crossmatches in the Absence of Donor-Specific Anti-Human Leukocyte Antigen Antibodies: A Single-Center Experience

Kang H, Yoo J, Lee SY, Oh EJ

Pretransplant crossmatch (XM) testing is widely used for detecting preformed donor-specific antibodies (DSAs) against human leukocyte antigen (HLA). However, in some cases, there is a positive XM result in the...
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Identification of 8-Digit HLA-A, -B, -C, and -DRB1 Allele and Haplotype Frequencies in Koreans Using the One Lambda AllType Next-Generation Sequencing Kit

Choe W, Chae JD, Yang JJ, Hwang SH, Choi SE, Oh HB

Background: Recent studies have successfully implemented next-generation sequencing (NGS) in HLA typing. We performed HLA NGS in a Korean population to estimate HLA-A, -B, -C, and -DRB1 allele and haplotype...
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Basic Verification of β-D Glucan in Leukocyte-Rich Plasma for the Diagnosis of Deep Mycosis

Shimoyama K, Kan S, Takahashi G, Morino G, Yamada Y, Inoue YI, Inada K, Endo S

Background: Currently, supplementary serological testing for β-D glucan (BDG) is often selected to diagnose deep mycosis in care covered by the health insurance in Japan. The Wako method used by...
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Allogeneic Fibrin Clot for Odontogenic/Cementogenic Differentiation of Human Dental Mesenchymal Stem Cells

Cao HL, Chung JH, Choung PH

BACKGROUND: Fetal bovine serum is widely used as a growth supplement for cell culture medium; however, animalbornepathogens increase the risk of transmitting infectious agents. Platelet-rich fibrin is recently considered as...
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Factors Predicting the Need for Early Surgical Intervention for Small Bowel Obstruction

Cho YJ, Park IS, Kim J, Cho HJ, Gwak GH, Yang KH, Bae BN, Kim KH

Purpose: Small bowel obstruction (SBO) is a common disease that requires hospitalization. The most common cause of SBO is postoperative adhesion. Delayed timing of operations in patients who need surgical...
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Evaluating the Performance of the Sysmex DI-60 Automated Cell Image Analyzer for the Differential Analysis of Leukocytes

Lee SY, Lee HT, Kwoun WJ, Lee YS, Ahn JY

Background: The Sysmex DI-60 system (Sysmex, Japan) is an automated cell image analyzer. This study aimed to evaluate the performance of the DI-60 system for the differential analysis of leukocytes. Methods:...
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Rodent Leukocyte Isolation and Radiolabeling for Inflammation Imaging Study

Kim EM, Oh PS, Boud F, Jeong HJ, Lim ST, Sohn MH

Purpose: The objective of this study was to describe to develop methods of rodent leukocyte isolation and radiolabeling for in vivo inflammation imaging. Methods: Thigh muscle inflammation was induced by injection...
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Maternal killer-cell immunoglobulin-like receptors and paternal human leukocyte antigen ligands in recurrent pregnancy loss cases in Turkey

Elbaşı MO, Tulunay A, Karagözoğlu H, Kahraman S, Ekşioğlu-Demiralp E

Objective: The survival of a semi-allogeneic fetus depends on several immunological mechanisms, and it has been suggested that recurrent pregnancy loss (RPL) could develop as a result of one or...
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Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation

Kim T, Choi Y, Lee JH, Park S, Ahn JS, Moon JH, Shin HJ, Lee WS, Kim D, Lee HS

Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses...
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Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population

Kim DK, Kim JY, Han YE, Kim JK, Lim HS, Eun KM, Yang SK, Kim DW

PURPOSE: Various immune cells, including eosinophils and neutrophils, are known to contribute to the development of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the current understanding of the role of...
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Clinical significance of donor-specific anti-HLA-DR51/52/53 antibodies for antibody-mediated rejection in kidney transplant recipients

Park BG, Park Y, Joo DJ, Huh KH, Kim MS, Kim SI, Kim YS, Kim HS

BACKGROUND: The presence of donor-specific antibodies (DSAs) to human leukocyte antigen (HLA) increases the risk of antibody-mediated rejection (ABMR) after kidney transplantation (KT). However, the clinical relevance of anti-HLA-DR51/52/53 antibodies...
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Analysis of differences in human leukocyte antigen between the two Wellcome Trust Case Control Consortium control datasets

Jang CS, Choi W, Cook S, Han B

The Wellcome Trust Case Control Consortium (WTCCC) study was a large genome-wide association study that aimed to identify common variants associated with seven diseases. That study combined two control datasets...
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Genetic aspects of type 1 diabetes

Lee HS, Hwang JS

Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of...
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Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature

Muneer A, Minhas FA

Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric...
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Significance of Differential Characteristics in Infantile Kawasaki Disease

Kwak JH, Lee J, Ha KS

BACKGROUND AND OBJECTIVES: Immunological variability in Kawasaki disease (KD) shows age-specific differences; however, specific differences in laboratory values have not been compared between infants and non-infants with KD. We compared...
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Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond

Nguyen DV, Vidal C, Chu HC, van Nunen

Despite their being uncommon, severe cutaneous adverse drug reactions (SCARs) result in a very great burden of disease. These reactions not only carry with them a high mortality (10%–50%) and...
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Comparison of acute phase reactant levels of Kawasaki disease patients who visited with less than 5 days duration of fever and with 5 days or longer

Do HJ, Jeong JH, Kim DH, Kim TY, Kang C, Lee SH, Lee SB

PURPOSE: Kawasaki disease (KD) is a common, acute systemic vasculitis in children. Acute phase reactants (APRs) have been used to assist diagnosis, and to predict outcome in children with KD....
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Validation of systemic inflammatory response syndrome criteria without white blood cell count in Korean Triage and Acuity Scale

Sun J, Chung H, Jang H, Kim S, Lee Y, Park J

OBJECTIVE: The systemic inflammatory response syndrome (SIRS) criteria used in the triage scale have been implemented incompletely without laboratory data, such as the white blood cell (WBC) count, so the...
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The Difference in Serum Ferritin and Leukocyte Regarding Overweight and Obese South Korean Adults

Lee HS

PURPOSE: The purpose of this study was to investigate the difference in serum ferritin and leukocyte regarding overweight and obese South Korean adults. METHODS: This study was conducted on 5,281 subjects...
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Review of Guidelines for the Evaluation and Treatment of Leukocytospermia in Male Infertility

Brunner RJ, Demeter JH, Sindhwani

Leukocytospermia is an ill-defined and poorly understood condition affecting up to 30% of male factor infertility. Current guidelines on leukocytospermia vary significantly, although it has been linked to increased rates...
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