- Inhibition of in vitro hepatitis B virus replication by lentivirus-mediated short-hairpin RNA against HBx
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Kim JW, Lee SH, Park YS, Jeong SH, Kim N, Lee DH
- KMID: 1776811
- Korean J Hepatol.
- 2009 Mar;15(1):15-24.
- doi: 10.3350/kjhep.2009.15.1.15
BACKGROUNDS/AIMS: Hepatitis B virus (HBV) replicates via RNA intermediates, which could serve as targets for RNA interference (RNAi). Vector-mediated short-hairpin RNA (shRNA) can induce sustained RNAi in comparison to small... -
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- Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo
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Wang XT, Xie YB, Xiao Q
- KMID: 1025167
- Exp Mol Med.
- 2011 Nov;43(11):638-645.
- doi: 10.3858/emm.2011.43.11.072
The E2F-1 transcription factor is post-translationally modified and stabilized in response to various forms of DNA damage to regulate the expression of cell-cycle and pro-apoptotic genes. The sustained overexpression of... -
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