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Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice

Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D

Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis. Delayed type hypersensitivity (DTH) is an immunologic response that has been frequently used as a correlate for protection...
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The Route of Leishmania tropica Infection Determines Disease Outcome and Protection against Leishmania major in BALB/c Mice

Mahmoudzadeh-Niknam H, Khalili G, Abrishami , Najafy A, Khaze V

Leishmania tropica is one of the causative agents of leishmaniasis in humans. Routes of infection have been reported to be an important variable for some species of Leishmania parasites. The...
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Viscerotropic growth pattern of Leishmania tropica in BALB/c mice is suggestive of a murine model for human viscerotropic leishmaniasis

Mahmoudzadeh-Niknam H, Kiaei SS, Iravani D

Leishmania (L.) tropica is a causative agent of cutaneous leishmaniasis, and occasionally of visceral or viscerotropic leishmaniasis in humans. Murine models of Leishmania infection have been proven to be useful...
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Miltefosine-Induced Apoptotic Cell Death on Leishmania major and L. tropica Strains

Khademvatan S, Gharavi MJ, Rahim F, Saki J

The aim of this study was to assess the cytotoxic effects of various concentrations of miltefosine on Leishmania major (MRHO/IR/75/ER) and L. tropica (MHOM/IR/02/Mash10) promastigotes and to observe the programmed...
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Genetic Diversity and Phylogenetic Analysis of the Iranian Leishmania Parasites Based on HSP70 Gene PCR-RFLP and Sequence Analysis

Nemati S, Fazaeli A, Hajjaran H, Khamesipour A, Anbaran MF, Bozorgomid A, Zarei F

Despite the broad distribution of leishmaniasis among Iranians and animals across the country, little is known about the genetic characteristics of the causative agents. Applying both HSP70 PCR-RFLP and sequence...
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Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review

Mohammadpour I, Motazedian MH, Handjani F, Hatam GR

Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by the Phlebotomus sand fly. The eyelid is rarely involved possibly because the movement of...
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A Case of Cutaneous Leishmaniasis Treated with Cryosurgery

Choi HM, Myung KB, Kook HI

  • KMID: 2231753
  • Korean J Dermatol.
  • 1983 Apr;21(2):207-211.
Cutaneous leishmaniasis (oriental sore) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. The disease is endemic to the Mediterranean, Asia, Africa, and the Middle...
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A Case of Scrotal Eczema with Calcified Nodules

Shin CS, Lee ES, Cho TH, Lee CJ

  • KMID: 2231754
  • Korean J Dermatol.
  • 1983 Apr;21(2):213-217.
Cutaneous leishmaniasis (oriental sore) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. The disease is endemic to the Mediterranean, Asia, Africa, and the Middle...
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A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica

Mostafavi , Khazaeli P, Sharifi I, Farajzadeh S, Sharifi H, Keyhani A, Parizi MH, Kakooei S

There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled...
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Five Cases of Cutaneous Leishmaniasis

Kim HJ, Shin DH, Kim YW

  • KMID: 2231702
  • Korean J Dermatol.
  • 1984 Feb;22(1):60-67.
Cutaneous leishmaniasis is a self-limited infection of the skin caused by Leishmania tropica, a protozoan parasite transmitted by Phlebotomus sandfly. This disease is endemic in tropical and subtropical zone, but...
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Antileishmanial and Cytotoxic Effects of Essential Oil and Methanolic Extract of Myrtus communis L.

Mahmoudvand H, Ezzatkhah , Sharififar F, Sharifi I, Dezaki ES

Plants used for traditional medicine contain a wide range of substances that can be used to treat various diseases such as infectious diseases. The present study was designed to evaluate...
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Antileishmanial Activity of Niosomal Combination Forms of Tioxolone along with Benzoxonium Chloride against Leishmania tropica

Parizi MH, Farajzadeh S, Sharifi I, Pardakhty , Parizi MH, Sharifi H, Salarkia E, Hassanzadeh S

In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by...
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Overexpression of Ubiquitin and Amino Acid Permease Genes in Association with Antimony Resistance in Leishmania tropica Field Isolates

Kazemi-Rad E, Mohebali M, Khadem-Erfan MB, Hajjaran H, Hadighi R, Khamesipour A, Rezaie S, Saffari M, Raoofian R, Heidari M

The mainstay therapy against leishmaniasis is still pentavalent antimonial drugs; however, the rate of antimony resistance is increasing in endemic regions such as Iran. Understanding the molecular basis of resistance...
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Epidemiological Aspects of Cutaneous Leishmaniasis during 2009–2016 in Kashan City, Central Iran

Moein D, Masoud D, Saeed M, Abbas D

Cutaneous leishmaniasis (CL) can be seen in 2 forms, zoonotic and anthroponotic, in Iran. In this study, epidemiological aspects of CL were studied during an 8-year period (2009–2016) in city...
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Evaluation of the Interventional Approaches in the Management of Cutaneous Leishmaniasis in Jazan: An Observational Study

Makeen HA, Buraik MA, Menachery , Alattas KM, Meraya AM

BACKGROUND: Cutaneous leishmaniasis is a tropical infection of public health importance. Numerous treatment approaches are in practice with variable degree of success however its management has no universal consensus or...
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