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In Reply: Trough Melatonin Levels Have No Physiological or Clinical Relevance

Lin CH, Lane HY

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Novel Biomarkers of Alzheimer’s Disease: Based Upon N-methylD-aspartate Receptor Hypoactivation and Oxidative Stress

Chiang TI, Yu YH, Lin CH, Lane HY

Early detection and prevention of Alzheimer's disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not...
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Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments

Lin E, Lin CH, Lane HY

A growing body of evidence now proposes that machine learning and deep learning techniques can serve as a vital foundation for the pharmacogenomics of antidepressant treatments in patients with major...
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Effects of Antipsychotics on Bone Mineral Density in Patients with Schizophrenia: Gender Differences

Chen CY, Lane HY, Lin CH

Low bone mineral density (BMD) and osteoporosis are common in patients with schizophrenia and detrimental to illness prognosis and life quality. Although the pathogenesis is not fully clear, series of...
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Venous Thromboembolism Following Dantrolene Treatment for Neuroleptic Malignant Syndrome

Chen PH, Lane HY, Lin CH

Neuroleptic malignant syndrome (NMS) is one of the most severe iatrogenic emergencies in clinical service. The symptoms including sudden consciousness change, critical temperature elevation and electrolytes imbalance followed by mutli-organ...
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Trough Melatonin Levels Differ between Early and Late Phases of Alzheimer Disease

Lin CH, Chiu CC, Lane HY

Objective: Melatonin has been considered to have an essential role in the pathophysiology of Alzheimer’s disease (AD) for its regulatory function on circadian rhythm and interaction with glutamate for the...
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