- Unmet need in chronic hepatitis B management
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Liang LY, Wong GL
- KMID: 2451920
- Clin Mol Hepatol.
- 2019 Jun;25(2):172-180.
- doi: 10.3350/cmh.2018.0106
Despite all these exciting developments, there remain some unmet needs in the management for patients with chronic hepatitis B (CHB). As majority of CHB patients are going to use oral... -
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- Safety and Effectiveness Analysis of Kivexa® (lamivudine/abacavir sulfate) in Human Immunodeficiency Virus Infected Korean Patients
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Ann H, Lee YS, Kim YS, Jung SI, Lee SH, Lee CS, Lee JS, Choi WS, Choi YH, Kim SW
- KMID: 2450871
- Infect Chemother.
- 2019 Jun;51(2):150-160.
- doi: 10.3947/ic.2019.51.2.150
BACKGROUND: Lamivudine and abacavir sulfate are widely used nucleoside/tide reverse transcriptase inhibitors (NRTI) backbone agents, which are recommended in major international treatment guidelines. The fixed-dose combination of lamivudine and abacavir... -
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- Therapeutic Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B
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Choi Y, Bae KS, Kim KH, Koh DK, Kim JH
- KMID: 2418539
- Pediatr Infect Vaccine.
- 2018 Aug;25(2):72-81.
- doi: 10.14776/piv.2018.25.e2
PURPOSE: This prospective study aimed to investigate the therapeutic efficacy of lamivudine in children with chronic hepatitis B virus (HBV) infection. METHODS: During July 2003 through October 2015, children with chronic... -
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- Direct Detection of Drug-Resistant Hepatitis B Virus in Serum Using a Dendron-Modified Microarray
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Kim DH, Kang HS, Hur SS, Sim S, Ahn SH, Park YK, Park ES, Lee AR, Park S, Kwon SY, Lee JH, Kim KH
- KMID: 2411679
- Gut Liver.
- 2018 May;12(3):331-341.
- doi: 10.5009/gnl17336
BACKGROUND/AIMS: Direct sequencing is the gold standard for the detection of drug-resistance mutations in hepatitis B virus (HBV); however, this procedure is time-consuming, labor-intensive, and difficult to adapt to high-throughput... -
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- A Multicenter Study of the Antiviral Efficacy of Entecavir Monotherapy Compared to Lamivudine Monotherapy in Children with Nucleos(t)ide-naïve Chronic Hepatitis B
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Lee KJ, Choe BH, Choe JY, Kim JY, Jeong IS, Kim JW, Yang HR, Chang JY, Kim KM, Moon JS, Ko JS
- KMID: 2403318
- J Korean Med Sci.
- 2018 Feb;33(8):e63.
- doi: 10.3346/jkms.2018.33.e63
BACKGROUND: The aim of this study was to compare the long-term efficacy of entecavir (ETV) and lamivudine (LAM) therapy in children with chronic hepatitis B (CHB) who had not received... -
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- Antiviral Efficacy of Tenofovir Monotherapy in Children with Nucleos(t)ide-naive Chronic Hepatitis B
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Choe JY, Ko JS, Choe BH, Kim JE, Kang B, Lee KJ, Yang HR
- KMID: 2399406
- J Korean Med Sci.
- 2018 Jan;33(2):e11.
- doi: 10.3346/jkms.2018.33.e11
BACKGROUND: The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection. Patients with CHB were treated... -
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- Efficacy and safety of entecavir versus lamivudine over 5 years of treatment: A randomized controlled trial in Korean patients with hepatitis B e antigen-negative chronic hepatitis B
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Lee KS, Kweon YO, Um SH, Kim BH, Lim YS, Paik SW, Heo J, Lee HJ, Kim DJ, Kim TH, Lee YS, Byun KS, Kim D, Lee MS, Yu K, Suh DJ
- KMID: 2406042
- Clin Mol Hepatol.
- 2017 Dec;23(4):331-339.
- doi: 10.3350/cmh.2016.0040
BACKGROUND/AIMS: Long-term data on antiviral therapy in Korean patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) are limited. This study evaluated the efficacy and safety of entecavir... -
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- Lamivudine: fading into the mists of time
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Choi J, Lim YS
- KMID: 2406039
- Clin Mol Hepatol.
- 2017 Dec;23(4):314-315.
- doi: 10.3350/cmh.2017.0110
No abstract available. -
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- Is it possible to predict the development of an entecavir resistance mutation in patients with chronic hepatitis B in clinical practice?
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Nam JY, Lee JH
- KMID: 2406038
- Clin Mol Hepatol.
- 2017 Dec;23(4):311-313.
- doi: 10.3350/cmh.2017.0069
No abstract available. -
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- Efficacy of tenofovir-based rescue therapy for chronic hepatitis B patients with resistance to lamivudine and entecavir
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Jeon HJ, Jung SW, Park NH, Yang Y, Noh JH, Ahn JS, Kim HR, Lee JH, Shin JW
- KMID: 2400670
- Clin Mol Hepatol.
- 2017 Sep;23(3):230-238.
- doi: 10.3350/cmh.2017.0003
BACKGROUND/AIMS: Tenofovir disoproxil fumarate (TDF) monotherapy for 48 weeks provided a virological response comparable to that of TDF and entecavir (ETV) combination therapy in patients infected with ETV-resistant hepatitis B... -
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- Management of Antiviral Resistance in Chronic Hepatitis B
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Lim YS
- KMID: 2412184
- Gut Liver.
- 2017 Mar;11(2):189-195.
- doi: 10.5009/gnl15562
The primary goal of therapy for chronic hepatitis B (CHB) is to prevent liver disease progression. Hepatitis B surface antigen (HBsAg) seroclearance or seroconversion is regarded as an optimal endpoint... -
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- Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study
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Cho EY, Yim HJ, Jung YK, Suh SJ, Seo YS, Kim JH, Kim HS, Lee SH, Ahn SH, Lee JI, Jeong SH, Kim JW, Lee JW, Kim IH, Kim HS, Park SJ, Lee JM, Hwang SG
- KMID: 2412164
- Gut Liver.
- 2017 Jan;11(1):129-135.
- doi: 10.5009/gnl15597
BACKGROUND/AIMS: Data are lacking regarding the management of chronic hepatitis B (CHB) with resistance to clevudine (CLV). This study evaluated the efficacy of different rescue therapies for CLV-resistant CHB. METHODS: Patients... -
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- Efficacy of switching from adefovir to tenofovir in chronic hepatitis B patients who exhibit suboptimal responses to adefovir-based combination rescue therapy due to resistance to nucleoside analogues (SATIS study)
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Lee HW, Park JY, Kim BK, Kim MY, Lee JI, Kim YS, Yoon KT, Han KH, Ahn SH
- KMID: 2373148
- Clin Mol Hepatol.
- 2016 Dec;22(4):443-449.
- doi: 10.3350/cmh.2016.0037
BACKGROUND/AIMS: It remains to be determined whether switching from adefovir (ADV) to tenofovir (TDF) provides better virological outcomes in patients exhibiting suboptimal responses to ADV plus nucleoside analogue (ADV+NA) therapy... -
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- Lamivudine versus Entecavir for Newly Diagnosed Hepatitis B Virus-Related Hepatocellular Carcinoma
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Kim JH, Sinn DH, Kim K, Kim H, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW
- KMID: 2412100
- Gut Liver.
- 2016 Nov;10(6):939-947.
- doi: 10.5009/gnl15527
BACKGROUND/AIMS: Antiviral therapy is a key component in the management of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients. However, whether the potent drug entecavir is more effective than a... -
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- Comparative Effectiveness of Lamivudine versus Entecavir in Patients with Hepatocellular Carcinoma: Watch out for Confounders!
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Kim HY
- KMID: 2412089
- Gut Liver.
- 2016 Nov;10(6):869-870.
- doi: 10.5009/gnl16476
No abstract available. -
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- Comparison of the clinical outcomes between antiviral-naïve patients treated with entecavir and lamivudine-resistant patients receiving adefovir add-on lamivudine combination treatment
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Kim HJ, Park SK, Yang HJ, Jung YS, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI, Choi KY
- KMID: 2373135
- Clin Mol Hepatol.
- 2016 Sep;22(3):350-358.
- doi: 10.3350/cmh.2016.0019
BACKGROUND/AIMS: To analyze the effects of preexisting lamivudine (LAM) resistance and applying antiviral treatment (adefovir [ADV] add-on LAM combination treatment) on long-term treatment outcomes, and comparing the clinical outcomes of... -
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- Analysis of Drug Utilization in Patients with Chronic Hepatitis B
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Lee YJ, Bae SJ, Je NK
- KMID: 2358238
- Korean J Clin Pharm.
- 2016 Sep;26(3):220-229.
- doi: 10.0000/kjcp.2016.26.3.220
BACKGROUND: The treatment goal for patients with chronic hepatitis B infection is to prevent progression of the disease to cirrhosis and hepatocellular carcinoma. Current therapies include standard and pegylated interferon-alfa... -
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- Comparison of tenofovir plus lamivudine versus tenofovir monotherapy in patients with lamivudine-resistant chronic hepatitis B
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Park CH, Jung SW, Shin JW, Bae MA, Lee YI, Park YT, Chung HS, Park NH
- KMID: 2363033
- Clin Mol Hepatol.
- 2016 Mar;22(1):152-159.
- doi: 10.3350/cmh.2016.22.1.152
BACKGROUND/AIMS: Tenofovir disoproxil fumarate (TDF) exhibits similar antiviral efficacy against treatment-naïve and lamivudine (LAM)-resistant chronic hepatitis B (CHB). However, there are few clinical reports on the antiviral effects of TDF-LAM... -
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- Entecavir Resistance at rtS202, rtM250 May Cause Poor Viral Response to Tenofovir-based Rescue Therapy in Chronic Hepatitis B
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Kim SE, Park JW, Kim HS, Suk KT, Jang MK, Park SH, Lee MS, Kim DJ, Park CK
- KMID: 2268953
- Korean J Med.
- 2015 Nov;89(5):527-536.
- doi: 10.3904/kjm.2015.89.5.527
BACKGROUND/AIMS: Long-term use of nucleos(t)ide analogues (NA) may lead to genotypic and/or phenotypic resistance of the hepatitis B virus (HBV). We investigated the efficacy of tenofovir-based rescue therapy in chronic... -
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- Entecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy
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Park JG, Park SY
- KMID: 2351024
- Clin Mol Hepatol.
- 2015 Sep;21(3):242-248.
- doi: 10.3350/cmh.2015.21.3.242
BACKGROUND/AIMS: We compared the efficacies of entecavir (ETV) plus tenofovir (TDF) and ETV plus adefovir (ADV) in chronic hepatitis B (CHB) patients with genotypic resistance to lamivudine (LAM) who showed... -
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