- Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells
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Shilnikova K, Piao MJ, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Cho SJ, Hyun JW
- KMID: 2526815
- Biomol Ther.
- 2022 Mar;30(2):137-144.
- doi: 10.4062/biomolther.2021.088
Radiation resistance represents an imperative obstacle in the treatment of patients with colorectal cancer, which remains difficult to overcome. Here, we explored the anti-proliferative and migration-inhibiting properties of the natural... -
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- The Endoplasmic Reticulum Stress Response Mediates Shikonin-Induced Apoptosis of 5-Fluorouracil–Resistant Colorectal Cancer Cells
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Piao MJ, Han X, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW
- KMID: 2529892
- Biomol Ther.
- 2022 May;30(3):265-273.
- doi: 10.4062/biomolther.2021.118
Resistance to chemotherapeutic drugs is a significant problem in the treatment of colorectal cancer, resulting in low response rates and decreased survival. Recent studies have shown that shikonin, a naphthoquinone... -
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- Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways
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Piao MJ, Kim KC, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Hyun JW
- KMID: 2510129
- Biomol Ther.
- 2021 Jan;29(1):90-97.
- doi: 10.4062/biomolther.2020.059
Ultraviolet B (UVB) radiation causes DNA base modifications. One of these changes leads to the generation of 8-oxoguanine (8-oxoG) due to oxidative stress. In human skin, this modification may induce... -
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