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Heterologous Regulation of BCG hsp65 Promoter by M. leprae 18 kDa Transcription Repression Responsive Element

Kim HB, You JC

  • KMID: 2053075
  • Genomics Inform.
  • 2003 Dec;1(2):113-118.
Among a number of antigens characterized in M. leprae, an etiological agent of Leprosy, the 18 kDa antigen, is unique to M. leprae. We have previously determined a sequence specific...
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Effects of Integrin avB5 and av B53 on the Adenovirus - Mediated Gene Transduction

Park JY, Joo SY, Jeon HS, Chang HJ, Kam S, Kim IS

  • KMID: 2175115
  • J Korean Cancer Assoc.
  • 2000 Apr;32(2):422-430.
PURPOSE: Human adenovirus, commonly used as a vector for gene therapy, enters host cells by receptor mediated endocytosis. Since integrin av B5 of cell surface promotes endocytosis of adenovirus and subsequent disruption...
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Lactoferrin as a gene delivery vehicle to hepatocytes

Oh ST, Rih JK, Kwon HS, Hwang DS, Kim SY, Yim JB

  • KMID: 2045606
  • Exp Mol Med.
  • 1997 Jun;29(2):111-116.
Using lactoferrin as the specific ligand, we developed a simplified method for preparation of molecular conjugate for gene delivery. Replacement of column chromatography and dialysis by one step centrifugal filtration...
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A simple human immunodeficiency virus vector system for selective infection of CD4(+) cells and inducible expression of foreign genes

Kim YS

  • KMID: 2045605
  • Exp Mol Med.
  • 1997 Jun;29(2):103-110.
The alteration of T lymphocyte functions as a consequence of human immunodeficiency virus (HIV) infection is a potential target for the genetic treatment of the acquired immunodeficiency syndrome (AIDS). One...
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Comparison of Efficiency of Infection of Human Cancer Cell Lines Via Retroviral Vector System

Kim YS, Lim HK, Kim JH, Min JS

  • KMID: 1531900
  • J Korean Cancer Assoc.
  • 1997 Feb;29(1):1-10.
PURPOSE: There are several reasons why retroviruses are useful as vectors for gene therapy. However, retroviral vectors also have some limitations. Research in retroviral-mediated gene transfer has struggled with low...
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Histological and Functional Changes after Transplantation of Human Mesenchymal Stem Cell in the Ischemic Rat Model

Kim HS, Song JY, Kim HS, Yun HU, Lee KB, Cho KG

  • KMID: 2256559
  • Korean J Cerebrovasc Surg.
  • 2005 Mar;7(1):61-68.
OBJECTIVES: Brain transplantation has emerged as an effective treatment for patients suffering from neurodegenerative diseases, including Parkinson's disease, Huntingtons disease and Stroke. We evaluated that cytokine inducted human mesenchymal stem...
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Development of Gene Therapy Strategy Using Plasmid and Adenovirus in Cervical Cancer Treatment

Lee JM, Kim SJ, NamKoong S, Cho SD, Hwang SJ, Park HR, Han YJ, Kim ST, Lee HY, Kim DJ, Park YS, Kim CK, Oh YK, Park SH, Ahn WS

  • KMID: 2269870
  • Korean J Obstet Gynecol.
  • 1999 Sep;42(9):2019-2027.
BACKGROUND: The basic treatment of malignant tumors is surgery, radiotherapy, chemotherapy. Even though, the object of these treatments is to kill cancer cells, they have limitations. So, in future studies...
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Construction of recombinant HSCC-1 adenovirus vector for oral cancer gene therapy

Kim CH, Kim JW, Kim MJ, Pyo SW

  • KMID: 2183811
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2005 Mar;27(2):103-109.
In spite of the ongoing advances, standard therapies for oral cancer still has some limitations in efficacy and in ability to prolong survival rate of advanced disease and result in...
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Induction of apoptosis in oral cancer cell line through an recombinant HCCS-1 adenovirus

Kim CH, Lee DJ, Lee LK, Kim MJ, Kim JW, Pyo SW

  • KMID: 1575786
  • J Korean Assoc Oral Maxillofac Surg.
  • 2005 Aug;31(4):306-311.
Despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with oral squamous cell carcinoma has not significantly improved over the past several decades. Gene therapy is currently...
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Changes of Transfection Efficiencies of Plasmid LacZ Genes in Human Gynecologic Cancer Cell Lines

Kim BH, Bae SM, Han YJ, Lee HS, Jo YS, Lee KH, Hur SY, Kim JH, Kim YW, Ro DY, Lee JM, Namkoong S, Kim DJ, Kim CK, Ahn WS

  • KMID: 2272332
  • Korean J Obstet Gynecol.
  • 2004 May;47(5):870-879.
OBJECTIVE: The transfection efficiencies of gynecologic cancer cell lines were investigated by different mediated transfection methods using recombinant LacZ plasmid (pRcCMVLacZ and pAAVCMVLacZ). METHODS: In this study, the gynecologic cancer cell...
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Cardiac expression profiles of the naked DNA vectors encoding vascular endothelial growth factor and basic fibroblast growth factor

Lee JS, Byun J, Kim JM, Kim CY, Kim BM, Chung JH, Jang Y, Kim DK

  • KMID: 1089454
  • Exp Mol Med.
  • 2005 Oct;37(5):447-456.
We investigated expression profiles and biological effects of the naked DNA vectors in the heart. To this end, naked DNA vector was injected into the apex of the beating rat...
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Combination of Mutated Herpes Simplex Virus (G207) with Radiation for the Treatment of Squamous Cell Carcinoma of the Head and Neck

Kim SH, Choi EC, Han DH, Han SJ, Kim JH, Nam JI, Kim KM

  • KMID: 2276000
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Feb;46(2):139-146.
BACKGROUND AND OBJECTIVES: G207 virus is an ideal candidate of oncolytic viral therapy. It is a multi-gene mutant of HSV-1 with a deletion at the gamma34.5 loci and a LacZ...
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Early nerve regeneration on the crushing injury model and the autogenous nerve graft model of rat sciatic nerve

Park JC, Ahn KM, Lee JH, Lee JH

  • KMID: 1580275
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2004 Jan;26(1):1-14.
The number of Schwann cell in the early nerve regeneration on the crushing injury model and the autogenous nerve graft model was analysed. And the change pattern of myelination and...
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Cathepsin L derived from skeletal muscle cells transfected with bFGF promotes endothelial cell migration

Chung JH, Im EK, Jin T, Lee SM, Kim SH, Choi EY, Shin MJ, Lee KH, Jang Y

Gene transfer of basic fibroblast growth factor (bFGF) has been shown to induce significant endothelial migration and angiogenesis in ischemic disease models. Here, we investigate what factors are secreted from...
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Adenovirus and Lipofectin Mediated p53 Gene Transfection Efficiency in Human Cervical Cancer Cell Lines and Xenografted Nude Mouse

Yeo KA, Jung JE, Lee HY, Lee BH, Kim TH, Cheung BS, Rho MS, Lee JM, Namkoong S, Park YS, Kim CK, Ahn WS

  • KMID: 2262277
  • Korean J Obstet Gynecol.
  • 2001 Jun;44(6):1137-1144.
BACKGROUND: The classical treatment of the cervical cancer is surgery, radiotherapy, chemotherapy. Even though the improvement of treatment successful rate, conventional therapy has some limitations. Recent cutting edge of cancer...
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