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Correction: Sheep as a large animal model for hearing research: comparison to common laboratory animals and humans

Lue PY, Oliver MH, Neef M, Thorne PR, Suzuki-Kerr H

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Effects of single housing on behavior, corticosterone level and body weight in male and female mice

Smolensky I, Zajac‑Bakri K, Mallien A, Gass P, Guzman R, Inta D

Background Experimental mice are often single-housed either for an individual analysis (feeding behavior, imag‑ ing, calorimetry) or as a stress paradigm (social isolation) in translational biomedical research. Reports of the influ‑ ence of single housing in rodents are conflicting...
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Flavonoids as therapeutics for myocardial ischemia-reperfusion injury: a comprehensive review on preclinical studies

Verma VK, Bhardwaj P, Prajapati V, Bhatia A, Purkait S, Arya DS

Ischemic heart disease is the most prevalent cause of death worldwide affecting both the gender of all age groups. The high mortality rate is due to damage of myocardial tissue that...
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Combined treatment with vitamin C, hydrocortisone and thiamine does not attenuate morbidity and mortality of septic sheep

Baljinnyam T, Fukuda S, Niimi Y, Prough D, Enkhbaatar P

Background Sepsis is associated with a highest mortality rate in the ICU. Present study tests the efficacy of combined therapy with vitamin C, hydrocortisone and thiamine (combined therapy) in the ovine model of sepsis induced by Pseudomonas aeruginosa. In this study, sepsis was induced...
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Assessment of immunopathological responses of a novel non‑chemical biocide in C57BL/6 for safe disinfection usage

Ku K, Chae J, Park W, La J, Lee S, Lee H

Background Water electrospray technology has been developed and extensively studied for its physical properties and potential application as a non-chemical biocide against airborne pathogens. However, there are still concerns regarding the safety and potential toxicity of inhaling water electrospray (WE) particles....
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Acute sleep deprivation‑induced hepatotoxicity and dyslipidemia in middle‑aged female rats and its amelioration by butanol extract of Tinospora cordifolia

Bajaj P, Kaur T, Singh A, Kaur G

Background Sleep deprivation (SD) due to an unhealthy lifestyle poses an oxidative challenge and is closely associated with an increased risk and prevalence of different metabolic disorders. Although the negative consequences of SD are well reported on mental health little is known about its...
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Anti-inflammatory and anti-arthritic activities of ethanolic extract of Myxopyrum serratulum A.W. Hill

Rani T S, Jeyabalan S, Dhanasekaran S, Sekar M, Subramaniyan V, Wong LS

Background Rheumatoid arthritis (RA) is a debilitating inflammatory disorder characterized by an overactive immune system targeting joints, leading to inflammation and intense pain. While current RA therapies effectively alleviate symptoms,...
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A maternal diet high in carbohydrates causes bradyarrhythmias and changes in heart rate variability in the offspring sex-dependent in mice

Arroyo-Carmona RE, Mitre-Velasco Y, Martinez-Laguna Y, Torres-Jácome J, Albarado-Ibañez A

Background Maternal obesity prepregnancy, as well as gestational overweight produced by high-sucrose diet, could be evolved to the cardiometabolic diseases in offspring during adulthood. Until then, the cardiometabolic diseases were...
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Protective effect of β-sitosterol against high-fructose diet-induced oxidative stress, and hepatorenal derangements in growing female sprague-dawley rats

Gumede NM, Lembede BW, Nkomozepi P, Brooksbank RL, Erlwanger KH, Chivandi E

Background Chronic consumption of a high-fructose diet causes oxidative stress that compromises kidney and liver health. β-sitosterol (Bst), a phytosterol, is a functional nutrient with health benefits. β-sitosterol antioxidant activity...
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