- Use of laboratory animals and issues regarding the procurement of animals for research in Korea
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Ahn N, Park J, Roh S
- KMID: 2544272
- Lab Anim Res.
- 2023 Jun;39(2):91-99.
- doi: 10.1186/s42826-023-00161-8
Background Laboratory animals remain critical to biomedical research, despite the increasing availability of alternative approaches. Indeed, scientists strive to reduce and refine and replace the use of laboratory animals, even in... -
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- Regenerative medicine owes to microsurgery
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Shirbache K, Nematian H, Nabian M
- KMID: 2544278
- Lab Anim Res.
- 2023 Jun;39(2):162-164.
- doi: 10.1186/s42826-023-00158-3
New findings in regenerative medicine have always been combined with numerous animal studies. Therefore, choos‑ ing the right translational animal model plays an important role in transferring as much basic... -
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- Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice
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Mieske P, Scheinpflug J, Yorgan T, Brylka L, Palme R, Hobbiesiefken U, Preikschat J, Lewejohann L, Diederich K
- KMID: 2544271
- Lab Anim Res.
- 2023 Jun;39(2):70-90.
- doi: 10.1186/s42826-023-00160-9
Background Enrichment of home cages in laboratory experiments offers clear advantages, but has been criticized in some respects. First, there is a lack of definition, which makes methodological uniformity difficult. Second,... -
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- Segmentation algorithm can be used for detecting hepatic fibrosis in SD rat
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Hwang J, Lim M, Han G, Park H, Kim Y, Park J, Jun S, Lee J, Cho J
- KMID: 2544276
- Lab Anim Res.
- 2023 Jun;39(2):146-153.
- doi: 10.1186/s42826-023-00167-2
Background Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug discovery. Many antifibrotic... -
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- SARS‑CoV‑2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID‑19 model
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Lee N, Lee Y, Hong S, On D, Yoon G, An S, Nam K, Seo J, Shin J, Choi Y, Oh S, Yun J, Lee H, Choi K, Seong J, Park J
- KMID: 2544279
- Lab Anim Res.
- 2023 Jun;39(2):165-171.
- doi: 10.1186/s42826-023-00157-4
Background The Omicron variant has become the most prevalent SARS-CoV-2 variant. Omicron is known to induce milder lesions compared to the original Wuhan strain. Fatal infection of the Wuhan strain into... -
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- Identification of proteins regulated by chlorogenic acid in an ischemic animal model: a proteomic approach
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Shah M, Kang J, Koh P
- KMID: 2544273
- Lab Anim Res.
- 2023 Jun;39(2):100-111.
- doi: 10.1186/s42826-023-00164-5
Background Cerebral ischemia is a serious neurological disorder that can lead to high morbidity and mortality. Chlorogenic acid is a polyphenol compound with antioxidant that can regulate proteins in cerebral ischemia.... -
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- Case report on successful treatment for brain abscess in a Japanese monkey (Macaca fuscata)
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Kimura T
- KMID: 2544277
- Lab Anim Res.
- 2023 Jun;39(2):154-161.
- doi: 10.1186/s42826-023-00165-4
Background A brain abscess in human beings is a focal infection of the central nervous system frequently characterized by areas of localized cerebritis and central necrosis surrounded by a well vascularized... -
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- Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy
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Totain E, Lindner L, Martin N, Misseri Y, Iché A, Birling M, Sorg T, Herault Y, Bousquet‑Melou A, Bouillé P, Duthoit C, Pavlovic G, Boullier S
- KMID: 2544274
- Lab Anim Res.
- 2023 Jun;39(2):112-126.
- doi: 10.1186/s42826-023-00166-3
Background Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the... -
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- Effects of isoflurane and xylazine on inducing cerebral ischemia by the model of middle cerebral artery occlusion in mice
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Won J, Ahmad Khan Z, Hong Y
- KMID: 2544280
- Lab Anim Res.
- 2023 Jun;39(2):172-178.
- doi: 10.1186/s42826-023-00163-6
Preclinical ischemic stroke studies extensively utilize the intraluminal suture method of middle cerebral artery occlusion (MCAo). General anesthesia administration is an essential step for MCAo, but anesthetic agents can lead... -
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- Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance
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Onoriode Igben V, Iju W, Itivere O, Oyem J, Akpulu P, Ahama E
- KMID: 2544275
- Lab Anim Res.
- 2023 Jun;39(2):127-145.
- doi: 10.1186/s42826-023-00162-7
Background Datura metel (DM) stramonium is a medicinal plant often abused by Nigerians due to its psychostimulatory properties. Hallucinations, confusion, agitation, aggressiveness, anxiety, and restlessness are reported amongst DM users. Earlier... -
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- Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin‑induced hypertensive diabetic rats
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Moke E, Omogbai E, Osagie‑Eweka S, Uchendu A, Obayuwana O, Okoro‑Akpandu E, Ben‑Azu B
- KMID: 2544270
- Lab Anim Res.
- 2023 Jun;39(2):58-69.
- doi: 10.1186/s42826-023-00159-2
Background Hypertension is a medical condition that often comorbidly exist in patients with type II diabetes. Therefore, it is very important to manage both conditions simultaneously to mitigate the complications and... -
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