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A survey on the use of mice, pigs, dogs and monkeys as animal models in biomedical research in Spain

Goñi-Balentziaga O, Ortega-Saez I, Vila S, Azkona G

Background: The use of animals in biomedical science remains controversial. An individual’s level of concern is generally influenced by their culture, previous or current experience with animals, and the specific...
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Establishment of a novel experimental model of infected anal fistula in rat

Zhao M, Wang A, Zhang L, Yu H

Refractory Crohn’s-like enterocutaneous fistula indicates the aggressive manifestation and lead to poor prognosis of patients. The development of multidisciplinary strategies for fistula administration largely subjects to the deficiency of animal...
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Application time and persistence of transcranial direct current stimulation (tDCS) against neuronal death resulting from transient cerebral ischemia

Lee JH, Jung BH, Yoo KY

Background: Transcranial direct current stimulation (tDCS) has been studied as a tool to stimulate the functional recovery of neurons after stroke. Although this device has recently begun to be utilized...
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Laboratory information management system for COVID-19 non-clinical efficacy trial data

Yoon S, Noh H, Jin H, Lee S, Han S, Kim SH, Kim J, Seo JS, Kim JJ, Park IH, Oh J, Bae JY, Lee GE, Woo SJ, Seo SM, Kim NW, Lee YW, Jang HJ, Hong SM, An SH, Lyoo KS, Yeom M, Lee H, Jung B, Yoon SW, Kang JA, Seok SH, Lee YJ, Kim SY, Kim YB, Hwang JY, On D, Lim SY, Kim SP, Jang JY, Lee H, Kim K, Lee HJ, Kim HB, Park JW, Jeong DG, Song D, Choi KS, Lee HY, Choi YK, Choi Ja, Song M, Park MS, Seo JY, Nam KT, Shin JS, Won S, Yun JW, Seong JK

Background: As the number of large-scale studies involving multiple organizations producing data has steadily increased, an integrated system for a common interoperable format is needed. In response to the coronavirus...
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Retinoic acid regulates the ubiquitin– proteasome system in a middle cerebral artery occlusion animal model

Kang JB, Shah MA, Park DJ, Koh PO

Background: Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons. The ubiquitin–proteasome system is an important biological system that...
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Real-time observation of neutrophil extracellular trap formation in the inflamed mouse brain via two-photon intravital imaging

Byun DJ, Kim YM, Hyun YM

Intravital imaging via two-photon microscopy (TPM) is a useful tool for observing and delineating biological events at the cellular and molecular levels in live animals in a time-lapse manner. This...
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Efficacy of instillation of MB49 cells and thermoreversible polymeric gel in urothelial bladder carcinoma immunization

Santana JPP, Marcato PD, Massaro TNC, Godoy NL, Anibal FdF, Borra RC

Background: Activating the immune system for therapeutic benefit has long been a goal in immunology, especially in cancer treatment, but the low immunogenicity of antitumor vaccines remains a limiting factor...
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