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Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice

Yun WB, Kim JE, Lee ML, Choi JY, Park JJ, Song BR, Kang BC, Nam KT, Lee HW, Hwang DY

Background: This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorigenic phenotypes including...
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Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks

Choi YJ, Kim JE, Lee SJ, Gong JE, Jin YJ, Seo S, Lee JH, Hwang DY

Background: The oral administration of polystyrene-microplastics (PS-MPs) causes chronic constipation of ICR mice, but there are no reports on their effects on the inflammatory response in the colon. To determine...
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Ventilator-induced lung-injury in mouse models: Is there a trap?

Joelsson JP, Ingthorsson S, Kricker J, Gudjonsson T, Karason S

Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to the mechanical strain of ventilation, damage can...
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Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study

Cho DW, Han HY, Yang MJ, Woo DH, Han SC, Yang YS

Background: Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device,...
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Reduced receptor for advanced glycation end products is associated with α-SMA expression in patients with idiopathic pulmonary fibrosis and mice

Baek H, Jang S, Park J, Jang J, Lee J, Hong SH, Kim WJ, Park SM, Yang SR

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. Despite alveolar epithelial cells is crucial role in lung, its contribution and the associated biomarker remain unknown...
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Comparison of cisplatin-induced anti-tumor response in CT26 syngeneic tumors of three BALB/c substrains

Gong JE, Jin YJ, Kim JE, Choi YJ, Lee SJ, Kim KS, Jung YS, Cho JY, Lim Y, Kang HG, Hwang DY

Background: To determine whether the background of BALB/c substrains affects the response to anti-tumor drugs, we measured for alterations in tumor growth, histopathological structure of the tumor, and expressions of...
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