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Retraction Note: Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats

Yu JY, Nguyen HT, Yong CS, Park HG, Jun JH, Kim JO

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Animal models for the risk assessment of viral pandemic potential

Park MS, Kim JI, Bae JY, Park MS

Pandemics affect human lives severely and globally. Experience predicts that there will be a pandemic for sure although the time is unknown. When a viral epidemic breaks out, assessing its...
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Zebrafish as an alternative animal model in human and animal vaccination research

Bailone RL, Fukushima HCS, Fernandes BHV, Aguiar LKD, Corrêa T, Janke H, Setti PG, Oliveira Roça RD, Borra RC

Much of medical research relies on animal models to deepen knowledge of the causes of animal and human diseases, as well as to enable the development of innovative therapies. Despite...
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Highlights on selected microscopy techniques to study zebrafish developmental biology

Abu-Siniyeh A, Al-Zyoud W

Bio-imaging is a tedious task when it concerns exploring cell functions, developmental mechanisms, and other vital processes in vivo. Single-cell resolution is challenging due to different issues such as sample...
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Enhanced alcohol degradation and hepatic protective effects of an Acetobacter Pasteurianus-derived product, CureZyme-ACE, in an acute intoxication rat model

Jeon EJ, Cho YS, Kim AH, Shim JM, Kim YS, Piao Z, Shin YC, Kwon J

Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute intoxication rats. The...
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Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Kim KH, Jo JH, Cho HJ, Park TS, Kim TM

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived...
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Evaluation of canine teeth crown reduction technique in macaques

Kim SM, Kim JM

Background:The reduction of canine teeth in adult males in whom permanent canine teeth eruption occurs should be considered due to the safety of humans or other monkeys. The objective of...
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Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna

Ahn Y, Seo J, Park J, Won J, Yeo HG, Kim K, Jeon CY, Huh JW, Lee SR, Lee DS, Lee Y

To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the pathology...
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Rodent models for psychiatric disorders: problems and promises

Baker M, Hong SI, Kang S, Choi DS

Psychiatric disorders are a prevalent global health problem, over 900 million individuals affected by a continuum of mental and substance use disorders. Due to this high prevalence, and the substantial...
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Patient-derived xenografts as compatible models for precision oncology

Cho SY

Cancer is a very heterogeneous disease, displaying heterogeneity between patients (inter-tumoral heterogeneity) and heterogeneity within a patient (intra-tumoral heterogeneity). Precision oncology is a diagnostic and therapeutic approach for cancers based...
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Decrease of 14–3-3 proteins by glutamate exposure in the cerebral cortex of newborn rats

Kang JB, Lee SY, Park DJ, Koh PO

Glutamate is a representative excitatory neurotransmitter. However, excessive glutamate exposure causes neuronal cell damage by generating neuronal excitotoxicity. Excitotoxicity in neonates caused by glutamate treatment induces neurological deficits in adults....
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