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Newly dentified members of the TNF recept or superfamily (mTNFRH1 and mTNFRH2) inhibit T-cell proliferation

Kim J, La S, Kim BS, Kwon BS, Kwon B

  • KMID: 1094695
  • Exp Mol Med.
  • 2003 Jun;35(3):154-159.
By searching an EST database, we identified two TNF receptor superfamily members (named mTNFRH1 and mTNFRH2). Amino acid sequences are highly conserved between the two receptors (78% identity). The chromosomal...
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In vivo ligation of glucocorticoid-induced TNF receptor enhances the T-cell immunity to herpes simplex virus type 1

La S, Kim E, Kwon B

  • KMID: 1056231
  • Exp Mol Med.
  • 2005 Jun;37(3):193-198.
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially expressed on CD4+CD25+ regulatory T cells and GITR signals break the suppressive...
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Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses

Kim J, Choi SP, La S, Seo JS, Kim KK, Nam SH, Kwon B

  • KMID: 1119332
  • Exp Mol Med.
  • 2003 Dec;35(6):509-517.
4-1BB, a transmembrane molecule, member of the tumor necrosis factor receptor superfamily, is an important costimulatory molecule in the immune response, plays a key role in the clonal expansion and...
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