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PIM Kinase as an Executional Target in Cancer

Zhang X, Song M, Kundu JK, Lee MH, Liu ZZ

PIM (proviral integration site for moloney murine leukemia virus) kinase plays a key role as an oncogene in various cancers including myeloma, leukemia, prostate and breast cancers. The aberrant expression...
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Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells

Lee MH, Kundu JK, Keum YS, Cho YY, Surh YJ, Choi BY

Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional...
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Inhibition of Phorbol Ester-induced Mouse Skin Tumor Promotion and COX-2 Expression by Celecoxib: C/EBP as a Potential Molecular Target

Chun KS, Kundu JK, Park KK, Chung WY, Surh YJ

  • KMID: 2166060
  • Cancer Res Treat.
  • 2006 Jun;38(3):152-158.
PURPOSE: Inflammation acts as a driving force for the development of cancer. Multiple lines of evidence suggest that nonsteroidal anti-inflammatory drugs, especially those that specifically target cyclooxygenase-2 (COX-2), are effective...
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