- Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
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Jang SB, Kim D, Kim SY, Park C, Jeong JH, Kuh HJ, Lee J
- KMID: 1432757
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):9-13.
- doi: 10.4196/kjpp.2013.17.1.9
The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion... -
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- Development of Estimation Methods of Skin Oxidation and Evaluation of Anti-Oxidative Effects of Genistein in Topical Formulations
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Kim SY, Na YJ, Kim D, Kim Y, Kim HM, Hwang SH, Kwak J, Kuh HJ, Lee J
- KMID: 1768015
- Korean J Physiol Pharmacol.
- 2012 Jun;16(3):205-209.
- doi: 10.4196/kjpp.2012.16.3.205
The objective of the present study was to establish the method of measurement of hydrogen peroxide and to estimate the anti-oxidative effect of genistein in the skin. UVB induced skin... -
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- microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
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Lee H, Kim C, Kang H, Tak H, Ahn S, Yoon SK, Kuh HJ, Kim W, Lee EK
- KMID: 2382689
- Exp Mol Med.
- 2017 May;49(5):e327.
- doi: 10.1038/emm.2017.33
Acquisition of resistance to anti-cancer drugs is a significant obstacle to effective cancer treatment. Although several efforts have been made to overcome drug resistance in cancer cells, the detailed mechanisms... -
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- Clinical Pharmacokinetics of Tegafur Administered with Epirubicin and Cisplatin in Patients with Advanced Gastric Cancer
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Kang JH, Kim YL, Cho HK, Lee ES, Cha SJ, Hong YS, Lee KS, Kuh HJ
- KMID: 2166181
- Cancer Res Treat.
- 2003 Jun;35(3):224-231.
PURPOSE: Tegafur, an oral prodrug of 5-fluorouracil (5-FU), has been used in the treatment of gastric cancers. UFT (tegafur + uracil) has been developed to enhance the efficacy of tegafur.... -
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- Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells
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Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ
- KMID: 2427513
- Biomol Ther.
- 2018 Nov;26(6):591-598.
- doi: 10.4062/biomolther.2018.061
Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases... -
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- Antitumor Activity of Oxaliplatin, 5-FU and Paclitaxel Given Alone or in Combination with ZD1839 in Human Gastric Carcinoma Cells in vitro
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Jang JH, Lee SH, Kang JH, Sun HS, Nishio K, Saijo N, Kuh HJ
- KMID: 1972943
- Cancer Res Treat.
- 2002 Oct;34(5):372-381.
PURPOSE: Oxaliplatin (LOHP), 5-FU, and paclitaxel (PTX) are considered highly active against advanced gastric carcinomas, and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, ZD1839 is considered as a... -
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