- Toll-like receptor signal transduction
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Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S
- KMID: 756065
- Exp Mol Med.
- 2007 Aug;39(4):421-438.
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation... -
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- Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling
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Krishnan J, Choi S
- KMID: 1806244
- Genomics Inform.
- 2012 Sep;10(3):153-166.
- doi: 10.5808/GI.2012.10.3.153
A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of... -
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- Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout mice
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Krishnan J, Chen J, Shin KJ, Hwang JI, Han SU, Lee G, Choi S
- KMID: 1104803
- Exp Mol Med.
- 2008 Oct;40(5):495-504.
- doi: 10.3858/emm.2008.40.5.495
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-),... -
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