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Kim JH, Kim JC, Shin SH, Chang SI, Lee HS, Chung SI
KMID: 1029928
Exp Mol Med.
1999 Dec;31(4):203-209.
Angiostatin is a potent angiogenesis inhibitor that is composed of the first
four kringles of plasminogen fragment. Angiostatin with one less kringle
molecule (kringle 1 to 3) was...
BACKGROUND: Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein that is assembled from a low density lipoprotein(LDL) and apolipoprotein(a) [apo(a)]. The variations in Lp(a) concentration tend to be inversely related to the...
BACKGROUND: Vascular endothelial growth factor (VEGF) plays a role in the development of cancer and the progression of liquid tumors such as chronic lymphatic leukemia, non-Hodgkin lymphomas, and multiple myeloma....
Kim KS, Hong YK, Lee Y, Shin JY, Chang SI, Chung SI, Joe YA
KMID: 1119342
Exp Mol Med.
2003 Dec;35(6):578-585.
The serine protease urokinase-type plasminogen activator (uPA) is implicated in pericellular proteolysis in a variety of physiological and pathological processes including angiogenesis and tumor metastasis. The kringle domain of uPA...
PURPOSE: Angiostatin, a 38 kDa internal fragment of plasminogen, is a potent inhibitor of angiogenesis. It blocks neovascularization and growth of primary and metastatic tumors in mice. To produce recombinant...