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Metastasis-associated protein 1: a druggable target in cancer treatment

Pulaganti M, Soma KA, Mandla R, Cherukuthota B, Dudekula H

Cancer treatment has undergone significant transformation with the emergence of molecularly targeted drugs, aiming to exploit specific vulnerabilities within cancer cells while sparing normal tissues. One critical aspect of this...
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Alterations in portal vein confluence during gastric cancer surgery: two case reports

Kim SH, Signorini FJ, Park K, Kim C, Kim J, Cho YS, Kong SH, Park DJ, Lee HJ, Yang HK

This article presents two cases of extrahepatic portal vein anomalies that can be challenging during lymph node (LN) dissection in gastric cancer surgery. The first case was a participant for...
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Resident shortages and their impact on surgical care, defensive medicine, and patient management: a retrospective study in South Korea

Han JH, Lee BC, Choi JB, Jo HJ, Park JK, Kim HJ, Park EJ, Jung YH, Choi CI

Purpose: This study aimed to evaluate the impact of declining surgical residency program enrollment on patient care and outcomes in colorectal cancer surgeries. Methods: This retrospective observational study included 676 patients...
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Prognostic significance of tumor budding in endometrial cancer: clinicopathological insights

Dubey A, Ahuja S, Zaheer S

Purpose: Endometrial cancer is one of the most common gynecological cancers worldwide, with rising incidence rates. Despite therapeutic advances, it remains a significant cause of cancer-related deaths. Tumor budding (TB),...
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Developing cancer vaccine with carcinoembryonic antigen and IGF-1R as immunostimulants using immunoinformatics approach

Ezediuno LO, Ockiya MA, Awoniyi LO, Sangodare AO, David KB, Robert FO

Purpose: Colorectal cancer (CRC) remains a significant global health burden, necessitating innovative approaches for prevention and treatment. This study proposes a multiepitope vaccine targeting carcinoembryonic antigen (CEA) and insulin-like growth...
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Tumor budding in invasive breast carcinoma and its association with clinicopathological parameters: an experience from a tertiary care center in India

Shah A, Malik S, Khan AA, Ahluwalia C

Purpose: Breast cancer is one of the most common cancers globally, with an increasing incidence rate. It is a heterogeneous disease, and early metastasis remains a challenge. Tumor budding, defined...
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