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The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective

Chong CXZ, Koh FH, Tan HL, Sivarajah SS, Ng JL, Ho LML, Aw DKL, Koo WH, Han S, Koo SL, Yip CSP, Wang FQ, Foo FJ, Tan WJ

Purpose: Total neoadjuvant therapy (TNT) is becoming the standard of care for locally advanced rectal cancer. However, surgery is deferred for months after completion, which may lead to fibrosis and...
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Effects of Long-term Intermittent Oxygen Administration on the Cognitive Function in Rats

Koo SL, Kim CH, Ahn HC, Kim DW, Kim KH, Kim C

BACKGROUND: Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term...
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Effects of Capsicum Plaster at the Korean Hand Acupuncture Point on Pain Management after Knee Replacement

Lee HJ, Kim KS, Koo SL

BACKGROUND: Controlling postoperative pain after knee replacement while reducing opioid-induced adverse effects and improving outcomes remains an important challenge. To assess the effect of combined capsicum plaster at the...
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