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C1qa deficiency in mice increases susceptibility to mouse hepatitis virus A59 infection

Kim HW, Seo SM, Kim JY, Lee JH, Lee HW, Choi YK

Background: Mouse hepatitis virus (MHV) A59 is a highly infectious pathogen and starts in the respiratory tract and progresses to systemic infection in laboratory mice. The complement system is an...
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Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse

Lee MY, Kang JS, Go RE, Byun YS, Wi YJ, Hwang KA, Choi JH, Kim HC, Choi KC, Nam KH

Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α)...
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Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW

Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of...
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Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models

Sung YH, Ali M, Lee HW

Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential...
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Studies on In Vivo Function of Peroxiredoxins in Knockout Mice

Yu DY

Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,...
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Difference in Resistance to Streptococcus pneumoniae Infection in Mice

Jeong DG, Jeong ES, Seo JH, Heo SH, Choi YK

Streptococcus pneumoniae is a major pathogen that causes various diseases, including pneumonia and sepsis, as millions of people suffer from S. pneumoniae infection worldwide. To better understand the immune and...
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Morphologic Change of the Vestibular Organ in the Na+-K+-2Cl- Cotransporter Deficiency Mouse

Lee JH, Choi JY, Jung SH, Lee WS

  • KMID: 1603821
  • J Korean Bal Soc.
  • 2006 Jun;5(1):21-28.
BACKGROUND AND OBJECTIVES: The Na+-K+-2Cl- cotransporter-1 (NKCC1) is a member of the cation-coupled chloride transporter that participates in salt transport and cell volume regulation in diverse tissues. NKCC1 deficient mice...
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