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Pathologic findings of Fabry nephropathy: the pivotal role of kidney biopsy

Shin Jh, Kim SH

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The role of the gut microbiota in acute kidney injury: a new therapeutic candidate?

Kim CH, Moon SJ

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When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury

An JN, Kim SG, Song YR

Acute kidney injury (AKI) is a common condition in critically ill patients, and may contribute to significant medical, social, and economic consequences, including death. Although there have been advances in...
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Fructose in the kidney: from physiology to pathology

Nakagawa T, Kang DH

The Warburg effect is a unique property of cancer cells, in which glycolysis is activated instead of mitochondrial respiration despite oxygen availability. However, recent studies found that the Warburg effect...
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The roles of sodium and volume overload on hypertension in chronic kidney disease

Shin J, Lee CH

Chronic kidney disease (CKD) is associated with increased risk of cardiovascular (CV) events, and the disease burden is rising rapidly. An important contributor to CV events and CKD progression is...
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Hereditary kidney diseases associated with hypomagnesemia

Claverie-Martin F, Perdomo-Ramirez A, Garcia-Nieto V

In the kidney, a set of proteins expressed in the epithelial cells of the thick ascending loop of Henle and the distal convoluted tubule directly or indirectly play important roles...
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Executive Summary of the Korean Society of Nephrology 2021 Clinical Practice Guideline for Optimal Hemodialysis Treatment

Jung JY, Yoo KD, Kang E, Kang HG, Kim SH, Kim H, Kim HJ, Park TJ, Suh SH, Jeong JC, Choi JY, Hwang YH, Choi M, Kim YL, Oh KH, for the Clinical Practice Guideline Work Group

The Korean Society of Nephrology (KSN) has published a clinical practice guideline (CPG) document for maintenance hemodialysis (HD). The document, 2021 Clinical Practice Guideline on Optimal HD Treatment, is based...
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Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease

Cho IJ, Kang SM

Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades....
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Fabry nephropathy before and after enzyme replacement therapy: important role of renal biopsy in patients with Fabry disease

Kim IY, Lee HJ, Cheon CK

Background: In Fabry disease, the presence of globotriaosylceramide (GL3) deposits in various kidney cells leads to progressive renal dysfunction. However, kidney biopsy studies in patients with Fabry disease are limited....
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Metformin use and cardiovascular outcomes in patients with diabetes and chronic kidney disease: a nationwide cohort study

Kim MH, Oh HJ, Kwon SH, Jeon JS, Noh H, Han DC, Kim H, Ryu DR

Background: Metformin has recently been shown not to increase the risk of lactic acidosis in patients with chronic kidney disease (CKD). Thus, the criteria for metformin use in this population...
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Probiotics partially attenuate the severity of acute kidney injury through an immunomodulatory effect

Yang J, Ji GE, Park MS, Seong YJ, Go YS, Lee HY, Fang Y, Kim MG, Oh SW, Cho WY, Jo SK

Background: A healthy microbiome helps maintain the gut barrier and mucosal immune tolerance. Previously, we demonstrated that acute kidney injury (AKI) provoked dysbiosis, gut inflammation, and increased permeability. Here, we...
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Effects of the route of erythropoietin administration on hemoglobin variability and cardiovascular events in hemodialysis patients

Kim DH, Lee YK, Kim J, Park HC, Yun KS, Cho A, Yoon JW, Koo JR, Noh JW

Introduction: Despite the routine use of erythropoietin in hemodialysis patients to correct anemia, its administration route’s effects on hemoglobin variability and cardiovascular events remain elusive. Herein, we determined different erythropoietin...
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Metabolic risks in living kidney donors in South Korea

Kang E, Park J, Kim HJ, Park S, Park M, Kim Y, Kim K, Park SM, Chae DW, Chin HJ, Lee JP, Lee S, Kim SW, Cho JH, Han M, Kim YC, Kim YS, Choi I, Lee H

Background: Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney...
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Neutrophil extracellular traps and heparin-induced antibodies contribute to vascular access thrombosis in hemodialysis patients

Lee HW, An JN, Lee HS, Song YR, Kim HJ, Kim SG, Kim JK

Background: Anti-heparin/platelet factor 4 (PF4) antibodies may trigger severe thrombotic complications in hemodialysis (HD) patients. Tetrameric PF4 has a high affinity for extracellular DNA, which is a key component of...
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Renal outcomes of laparoscopic versus open surgery in patients with rectal cancer: a propensity score analysis

Paek JH, Kang SI, Ryu J, Lim SY, Ryu JY, Son HE, Jeong JC, Chin HJ, Na KY, Chae DW, Kang SB, Kim S

Background: A laparoscopic approach is widely used in abdominal surgery. Although several studies have compared surgical and oncological outcomes between laparoscopic surgery (LS) and open surgery (OS) in rectal cancer...
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Clinical outcomes and prognostic factors of mortality in liver cirrhosis patients on continuous renal replacement therapy in two tertiary hospitals in Korea

Jeon YH, Kim IY, Jang GS, Song SH, Seong EY, Lee DW, Lee SB, Kim HJ

Background: Data on liver cirrhosis (LC) patients undergoing continuous renal replacement therapy (CRRT) are lacking despite the dismal prognosis. We therefore evaluated clinical characteristics and predictive factors related to mortality...
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Hepatocyte growth factor and soluble cMet levels in plasma are prognostic biomarkers of mortality in patients with severe acute kidney injury

Li L, An JN, Lee J, Shin DJ, Zhu SM, Kim JH, Kim DK, Ryu DR, Kim S, Lee JP

Background: Hepatocyte growth factor (HGF)/cMet pathway is necessary for repair and regeneration following acute kidney injury (AKI). We evaluated the clinical potential of plasma HGF and soluble cMet as prognostic...
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Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease

Kim KW, Shin YJ, Kim BM, Cui S, Ko EJ, Lim SW, Yang CW, Chung BH

Background: Endothelial cell (EC) dysfunction is a frequent feature in patients with end-stage renal disease (ESRD). The aim of this study was to generate human induced pluripotent stem cells, differentiate...
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Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea

Yoo S, Cho MH, Baek HS, Song JY, Lee HS, Yang EM, Yoo KH, Kim SJ, Shin JI, Lee KH, Ha TS, Jang KM, Lee JW, Kim KH, Cho H, Lee MJ, Suh JS, Han KH, Hyun HS, Ha IS, Cheong HI, Kang HG, Namgoong MK, Cho HK, Oh JH, Lee ST, Kim KS, Lee JH, Park YS, Kim SH

Background: The clinical features of pediatric rhabdomyolysis differ from those of the adults with rhabdomyolysis; however, multicenter studies are lacking. This study aimed to investigate the characteristics of pediatric rhabdomyolysis...
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