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Established and Newly Proposed Mechanisms of Chronic Cyclosporine Nephropathy

Yoon HE, Yang CW

Cyclosporine (CsA) has improved patient and graft survival rates following solid-organ transplantation and has shown significant clinical benefits in the management of autoimmune diseases. However, the clinical use of CsA...
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Activation of Intrarenal Complement System in Mouse Model for Chronic Cyclosporine Nephrotoxicity

Kim YO, Lim SW, Li C, Kang HJ, Ahn KO, Yang HJ, Ghee JY, Kim SH, Kim JY, Choi BS, Kim J, Yang CW

PURPOSE: Local activation of the complement system plays a role in target organ damage. The aim of our study was to investigate the influence of cyclosporine (CsA)- induced renal injury...
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