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Extracorporeal circulation models in small animals: beyond the limits of preclinical research

Kayumov M, Habimana R, Kim D, Obiweluozor FO, Jeong IS, Cho HJ

Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with...
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Rat model of heterotopic heart transplantation to investigate relevant donor heart harvesting method

Kayumov M, Cho HJ, Kim DW, Lee KS, Jeong IS

Background: Various preservation methods have been describing to elongate implantable time of the donor heart as well as to eliminate post-transplant graft failure. There have been increasing concern about hypothermic...
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Comparison of hypothermic static and normothermic ex situ donor heart preservation in heterotopic heart transplantation with the murine model

Kayumov M, Kim DW, Cho HJ, Lee KS, Jeong IS

Background: Hypothermic static and normothermic ex situ preservation methods are the most widely used preservation technique worldwide. While cold static storage is associated with subsequent ischemic injury, normothermic perfusion preser-vation...
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A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model

Lee KS, Kayumov M, Emechebe GA, Kim DW, Cho HJ, Jeong YJ, Lee DW, Park JK, Park CH, Kim CS, Obiweluozor FO, Jeong IS

BACKGROUND: We have designed a reinforced drug-loaded vascular graft composed of polycaprolactone (PCL) and polydioxanone (PDO) via a combination of electrospinning/3D printing approaches. To evaluate its potential for clinical application,...
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