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Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures

Eun SY, Kim EH, Kang KS, Kim HJ, Jo SA, Kim SJ, Jo SH, Kim SJ, Blackshear PJ, Kim J

  • KMID: 1094157
  • Exp Mol Med.
  • 2006 Jun;38(3):310-319.
Myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed protein kinase C (PKC) substrate and has been implicated in actin cytoskeletal rearrangement in response to extracellular stimuli. Although MARCKS...
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Role of gamma-aminobutyric acid B (GABA B) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus

Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW

  • KMID: 1116198
  • Exp Mol Med.
  • 2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In...
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c-JUN Expression and Apoptotic Cell Death in Kainate-Induced Temporal Lobe Epilepsy

Lee MC, Rho JL, Kim MK, Woo YJ, Kim JH, Nam SC, Suh JJ, Chung WK, Moon JD, Kim HI

Following kainate (KA)-induced epilepsy, rat hippocampal neurons strongly ex-press immediate early gene (IEG) products, i.e., c-FOS and c-JUN, and neural stress protein, HSP72. Prolonged expression of c-JUN and c-FOS 48...
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Calcium/Calmodulin Kinase II Activity of Hippocampus in Kainate-Induced Epilepsy

Lee MC, Ban SS, Woo YJ, Kim SU

This study investigated calcium/calmodulin kinase II (CaMKII) activity related to long-standing neuronal injury of the hippocampus in kainate (KA)-induced experimental temporal lobe epilepsy. Epileptic seizure was induced by injection of...
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