- PI3Kδ contributes to ER stress-associated asthma through ER-redox disturbances: the involvement of the RIDD–RIG-I–NF-κB axis
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Kim HK, Lee GH, Bhattarai , Junjappa R, Lee HY, Handigund , Marahatta , Bhandary B, Baek IH, Pyo JS, Kim HK, Chai OH, Kim HR, Lee YC, Chae HJ
- KMID: 2440026
- Exp Mol Med.
- 2018 Feb;50(2):e444.
- doi: 10.1038/emm.2017.270
Hyperactivation of phosphoinositol 3-kinase (PI3K) has been suggested to be a potential mechanism for endoplasmic reticulum (ER) stress-enhanced airway hyperresponsiveness, and PI3K inhibitors have been examined as asthma therapeutics. However,... -
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