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Neolignan Derivatives from the Flower of Magnolia biondii Pamp. and their Effects on IL-2 expression in T-cells

Nguyen TT, Nguyen TT, Lee HS, Jun CD, Min BS, Kim JA

The isolation of the MeOH extract from the flower bud of Magnolia biondii Pamp. using various column chromatographies and HPLC led to eleven neoglignan derivatives (1 - 11). Their structures...
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Swiprosin-1 Expression Is Up-Regulated through Protein Kinase C-theta and NF-kappaB Pathway in T Cells

Kim YD, Kwon MS, Na BR, Kim HR, Lee HS, Jun CD

Swiprosin-1 exhibits the highest expression in CD8+ T cells and immature B cells and has been proposed to play a role in lymphocyte biology through actin remodeling. However, regulation of...
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Actin Engine in Immunological Synapse

Piragyte I, Jun CD

T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained...
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ICAM-1/LFA-1 interaction contributes to the induction of endothelial cell-cell separation: implication for enhanced leukocyte diapedesis

Wee H, Oh HM, Jo JH, Jun CD

The basic route and mechanism for diapedesis has not yet to be fully defined. Here we present evidence that "cell-cell separation" between endothelial cells (ECs) may provide a route for...
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Swiprosin-1 Regulates Cytokine Expression of Human Mast Cell Line HMC-1 through Actin Remodeling

Ramesh TP, Kim YD, Kwon MS, Jun CD, Kim SW

BACKGROUND: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in...
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Granulocyte Colony Stimulating Factor (G-CSF) Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-induced Colitis in Mice

Choi EY, Jun CD, Oh JM, Kim YR, Lee ST, Kim SW

BACKGROUND: Granulocyte colony stimulating factor (G-CSF) is known as a cytokine central to the hematopoiesis of blood cells and to modulate their cellular functions. Besides granulocytes and their precursors, monocytes/macrophages...
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Iron chelator inducesMIP-3alpha/CCL20 in human intestinal epithelial cells: implication for triggeringmucosal adaptive immunity

Lee HJ, Choi SC, Choi EY, Lee MH, Seo GS, Kim EC, Yang BJ, Lee MS, Shin YI, Park KI, Jun CD

  • KMID: 1093465
  • Exp Mol Med.
  • 2005 Aug;37(4):297-310.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokine IL-8, in human intestinal epithelial cells (IECs). Microarray-based gene...
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Involvement of Protein Kinase C delta in Iron Chelator-Induced IL-8 Production in Human Intestinal Epithelial Cells

Sohn YW, Choi EY, Han WC, Yun KJ, Oh JM, Jun CD

  • KMID: 2030768
  • Korean J Anat.
  • 2005 Feb;38(1):21-30.
Our previous study demonstrated that a bacterial siderophore, deferoxamine (DFO), could trigger inflammatory signals in human intestinal epithelial cells as a single stimulus, leading to IL-8 production via ERK1/2 and...
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Cytoplasmic Domain of Intercellular Adhesion Molecule-1(ICAM-1)is Important for the ICAM-1 Mediated Membrane Projection of Endothelial Cells

Seo GS, Choi M, Oh HM, Lee MH, Lee KM, Nah YH, Jun CD

  • KMID: 2030767
  • Korean J Anat.
  • 2005 Feb;38(1):11-19.
Intercellular adhesion molecule-1 (ICAM-1)has been shown to enhance leukocyte adhesion, thereby inducing migration through blood endothelial cells. However, the molecular event during the process of adhesion is largely unknown. To...
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Ulcerative Colitis is Associated with Novel Polymorphisms in the Promoter Region of MIP-3alpha/CCL20 Gene

Choi SC, Lee EK, Lee S, Chae SC, Lee MS, Seo GS, Kim SW, Yeom JJ, Jun CD

BACKGROUND: We examined global gene expression profiles of peripheral blood mononuclear cells (PBMCs) in patients with ulcerative colitis (UC), and tested whether the identified genes with the altered expression might...
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Rebamipide Protects Colonic Damage Induced by Trinitrobenzene Sulfonic Acid (TNBS) via Down-Regulation of TNF-alpha IL-1beta and ICAM-1

Kim YH, Kim SJ, Hwang HG, Choi SC, Kim YR, Kim KS, Kim C, Choi DH, Oh JT, Kim GD, Kim HW, Jun CD, Ryu CJ, Chung YT, Choi MK, Oh JM

  • KMID: 2030759
  • Korean J Anat.
  • 2004 Apr;37(2):149-155.
During inflammation of the colon, cells of the gut mucosa produce or express numerous inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1 beta), and intercellular adhesion molecule 1...
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The Effect of Iron Depletion on the Monocytic Adhesion, Differentiation and SR-A Expression

Seo GS, Choi SC, Choi EY, Kim TH, Nah YH, Oh JM, Kim SW, Jun CD

  • KMID: 2092852
  • Korean J Anat.
  • 2004 Dec;37(6):557-563.
Maintenance of cellular iron homeostasis is a prerequisite for proliferation and differentiation of cells, and is also a central role in the regulation of immune function. Monocyte-macrophages play an important...
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Effects of Sulphasalazine and Glucocorticoid on the Regulation of CCL20 Gene Expression in the Peripheral Blood Cells of Korean Patients with Ulcerative Colitis

Choi SC, Nah YH, Chung YT, Han WC, Lee MS, Jun CD

  • KMID: 2092851
  • Korean J Anat.
  • 2004 Dec;37(6):549-555.
Discovery of Nod2 has brought to light the significance of mononuclear cells as well as epithelial cells in inflammatory bowel disease (IBD) pathogenesis. Similarly, CCL20 is expressed in both mononuclear...
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Iron Chelator Induces MIP-3alpha/CCL20 in Human Intestinal Epithelial Cells: Implication for Triggering Mucosal Adaptive Immunity

Lee MS, Lee HJ, Han WC, Oh JM, Jun CD

  • KMID: 1609553
  • Korean J Phys Anthropol.
  • 2004 Dec;17(4):297-312.
A previous report by this laboratory demonstrated that bacterial iron chelator (siderophore) triggers inflammatory signals, including the production of CXC chemokie IL-8, in human intestinal epithelial cells(IECs). Microarray-based gene expression...
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Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages

Kim SW, Oh HM, Kim BS, Chung HT, Han WC, Kim EC, Kim TH, Seo GS, Lyou JH, Nah YH, Jung JC, Choi SC, Jun CD

  • KMID: 1088658
  • Exp Mol Med.
  • 2003 Feb;35(1):53-59.
Tumor target-derived soluble secretary factor has been known to influence macrophage activation to induce nitric oxide (NO) production. Since heme oxigenase-1 (HO-1) is induced by a variety of conditions associated...
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The Function of Dimeric Structure of Soluble Intercellular Adhesion Molecule - 1 ( sICAM-1 ): Inhibition of Leukocyte Function Associated Antigen - 1 ( LFA-1 ) Binding to ICAM-3

Choi SC, Han WC, Kim EC, Park DS, Oh HM, Oh JM, Jun CD

  • KMID: 1572921
  • J Bacteriol Virol.
  • 2002 Mar;32(1):99-108.
Intercellular adhesion molecule-1 (ICAM-1) is a membrane protein, exists as a dimer on the cell surface, and interacts with leukocyte function associated antigen-1 (LFA-1), a member of beta2-integrin family. A...
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Total Hepatitis C Virus Core Antigen Assay for Hepatitis C Virus Viremia and Comparison with RNA Assay

Park DS, Lee YJ, Lee KE, Cho JH, Kim HC, Jun CD, Kwak BH

  • KMID: 2239634
  • Korean J Lab Med.
  • 2002 Dec;22(6):431-436.
BACKGROUND: Recently, trak - C (Total HCV core antigen test; Ortho Clinical Diagnostics, Raritan, NJ, USA) that is based on the enzyme- linked immnunosorbent assay was developed. So, we tried...
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Nitric oxide-induced immune switching in experimental inflammatory autoimmune diseases

Kwak HJ, Kim HJ, Park JS, Jun CD, Lee MY, Shin TK, Chung HT

BACKGROUND: Nitric oxide (NO) production has been described as a double-edged sword eliciting both pro-and anti-inflammatory effect s in different immune reactions. This work was undertaken to investigate the immunoregulatory...
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Comparative Effects of Paclitaxel and Nitric Oxide on Superficial Murine Bladder Tumor Cells

Ahn BS, Kwak HJ, Bae HO, Yoo JC, Jun CD, Rim JS, Chung HT

  • KMID: 1646434
  • Korean J Immunol.
  • 2000 Dec;22(4):235-245.
No abstract available.
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The Role of Inducible 70-kDa Heat Shock Protein in Cell Cycle Control, Differentiation, and Apoptotic Cell Death of the Human Myeloid Leukemic HL-60 Cells

Jun CD

  • KMID: 1192680
  • Korean J Immunol.
  • 1998 Jun;20(2):249-262.
No abstract available.
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