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Amplification and Overexpression of c-erbB-2 in Gastric Cancer

Jun SY, Chung HY, Lee SC, Huh TL, Yu W

  • KMID: 2175010
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):467-475.
PURPOSE: We compared c-erbB-2 oncogene amplification and oncoprotein expression, trying to identify the biologic and prognostic significance of c-erbB-2 in adendegrees Carcinoma of the stomach. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections...
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Matrix Metalloproteinase Expression and Ldegrees Calization in Human Prostate Adendegrees Carcinoma: An Immunohistdegrees Chemical Study of MMP-2, -9, -3, -7

Shim JW, Lee YG, Lee TJ, Ro JY

  • KMID: 2175029
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):629-637.
No abstract available.
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Radioresponse of Hepatdegrees Celluar Carcinoma Treatment of Lymph Node Metastasis

Kim JH, Choi EK, Chung YW, Lee YS, Seo DJ

  • KMID: 2175022
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):571-577.
No abstract available.
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Frequency of bcl-2/JH Rearrangement in Benign Lymphoid Hyperplasia

Yoo YA, Lee SH, Son MN, Cho ZK, Choi K, Choi JW, Shin SW, Kim BS, Kim JS, Kim IS, Kim YH

  • KMID: 2175024
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):587-594.
No abstract available.
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The Role of bcl-2 and p53 in Tamoxifen-Induced Apoptosis of Human Breast Cancer Cell Lines

Noh WC, Noh DY, Ham YH, Kim CM, Paik NS, Moon NM, Choe KJ

  • KMID: 2175017
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):531-538.
PURPOSE: Tamoxifen has been well known as an effective anti-tumor agent against breast cancer. The important role of bcl-2 and p53 proteins in tamoxifen-induced apoptosis of breast cancer cells has been suggested....
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Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer; Significance of 5-FU Concentration Monitoring

Park YH, Kim BS, Ryoo BY, Kim TY, Im YH, Shin HS, Kang YK

  • KMID: 2175015
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):516-523.
PURPOSE: To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adendegrees Carcinoma and to elucidate the relationship between the pharmacokinetic (PK)...
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Retrospective Analysis of Treatment Results of Recurrent Gastric Cancer

Lee HJ, Cho SJ, Yang HK, Lee KU, Choe KJ, Kim JP

  • KMID: 2175014
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):506-515.
PURPOSE: Recurrent gastric cancer has a very poor prognosis due to its diagnostic difficulties, variant recurrence patterns and no effective treatment modalities. In this study, we retrospectively analyzed treatment results of the...
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Combination Chemotherapy with Etoposide, Doxorubicin, Cisplatin (EAP) for Recurred or Metastatic Gastric

Cancer Refractory to Prior Chemotherapy, Cho NK, Choi TS, Park YH, Lee SC, Yuh YJ, Kim SR

  • KMID: 2175016
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):524-530.
PURPOSE: We performed this study to evaluate the efficacy and the safety of EAP regimen as a second line therapy for the recurred or metastatic gastric cancer unresponsive to 5-fluorouracil based chemotherapy. MATERIALS...
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Construction of DNA Painting Probe for Transldegrees Cation Region of a Marker Chromosome by Chromosome Microdissection

Park CS, Lee IH, Choi IJ, Kim DK

  • KMID: 2175026
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):605-611.
PURPOSE: Chromosome microdissection has been recommended as a technology to overcome the limited problems of conventional cytogenetic analysis and is a direct approach to isolate DNA from specific interesting region of chromosome....
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Efficacy of Combination Chemotherapy with Vinorelbine, Ifosfamide, and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer

Chang HM, Lee JA, Ahn JS, Woo IS, Park YI, Son JW, Lee SJ, Kim DK, Mo EK, Park MJ, Lee MG, Hyun IG, Jung KS, Park YS

  • KMID: 2175027
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):612-618.
PURPOSE: To evaluate the efficacy and toxicity of combination chemotherapy with vinorelbine, ifosfamide, and cisplatin in patients with advanced non-small cell lung cancer. MATERIALS AND METHODS: Patients with unresectable, pathologically proven non-small...
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The Effect of Long-term Tamoxifen Therapy on Endometrium Evaluated by Transvaginal Sonography in Postmenopausal Women Undergone Breast Cancer Surgery

Bae JH, Kim LS, Kim JJ, Lim MK, Kim JH, Woo YM, Park MC, Kim DK, Choi CS, Kim S

  • KMID: 2175018
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):539-544.
PURPOSE: Tamoxifen is a non-steroidal antiestrogenic drug used mainly in the adjuvant therapy of breast cancer and it also has estrogenic effect to the endometrium. We investigated the effects of tamoxifen on...
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Expression of p53, p21/WAF1, bcl-2 and Loss of Heterozygosity for the Study of Apoptosis in Gastric Carcinoma

Yu HJ, Lee JH, Kim WH, Choe KJ, Kim JP

  • KMID: 2175008
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):447-457.
PURPOSE: The purpose of this study was to correlate the immunohistdegrees Chemical expressions of p53, p21 and bcl-2, with their loss of heterozygosity (LOH) and clinical significance. MATERIALS AND METHODS: Paraffin-embedded tissue...
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Expression of p21/WAF1/CIP1, p27/KIP1 and p57/KIP2 Proteins in Gastric Adendegrees Carcinoma

Park YE, Choi YH, Choi KC, Chae SW, Shin HS

  • KMID: 2175009
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):457-466.
PURPOSE: p21/WAF1/CIP1, p27/KIP1 and p57/KIP2 are negative regulators of the cell division cycle. We evaluated the expressions of KIP CDK inhibitors and examined the relationship of clinicopathologic parameters and cell proliferation index...
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Phase II Multicenter Trial of Paclitaxel for Metastatic Breast Cancer

Byun JH, Yoon SS, Park CH, Kim SR, Kim SY, Kim HJ, Bang SM, Chang HM, Heo DS, Bang YJ, Kim NK

  • KMID: 2175019
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):545-552.
PURPOSE: To evaluate the efficacy and safety of paclitaxel for metastatic breast cancer patients who had received previous chemotherapy, we have performed phase II multicenter trial between December 1997 and December 1998. MATERIALS...
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Expression of MDM-2 and p53 Proteins in Gastric Adendegrees Carcinoma and Its Relationship with Clinicopathologic Factors

Yang JW, Kim HJ, Lee TJ, Park ES, Yoo JH

  • KMID: 2175011
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):476-486.
PURPOSE: MDM-2 is an oncoprotein that inhibits p53 tumor-suppressor protein. These abnor malities have a role in tumorigenesis through inactivation of p53 function. To determine the clini copathological and prognostic value of...
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Clinical Significance of Apoptosis and p53 Protein Expression in Stage IIB Squamous Cell Carcinoma of the Cervix Treated with Radiotherapy Alone

Chung EJ, Kim GE, Seong J, Yang WI, Kim YT, Suh CO

  • KMID: 2175030
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):638-646.
PURPOSE: The purpose was to investigate the spontaneous apoptotic index (SAI) and p53 protein expression and to identify the role of SAI and p53 protein positivity. MATERIALS AND METHODS: Forty six patients...
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Interrelation between the Progression of Gastric Adendegrees Carcinoma and the Matrix Metalloproteinases

Lim SC, Lee MJ, Park CK

  • KMID: 2175013
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):497-505.
PURPOSE: An essential element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). But little is known about the role of them in the gastric adendegrees...
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Screening and Cloning of Genes Preferentially Expressed in Aminopterin-Treated Myeloma Cell Apoptosis

Lee HC, Kim SJ, Yoon S, Kwon SJ, Chung YH

  • KMID: 2175032
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):655-664.
PURPOSE: When murine myeloma cells P3-X63-Ag8.653 (V653) of this model treated with amin opterin, an anticancer drug, they can't synthesize nucleic acid via de novo or salvage pathway and selectively eliminated due...
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Regulation of Gene Expression in Murine Renal Cell Carcinoma Cells Growing in Ectopic or Orthotopic Organs of Syngenic Mice

Jung YS, Ahn KS, Kim J, Lee H, Yoon SS

  • KMID: 2175028
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):619-628.
PURPOSE: The biologic behavior of tumor cells is partially controlled by the microenvironment. We investigated the expression levels of several genes involved in metastasis and drug response in RENCA cells growing in...
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Production of Soluble VEGF Receptor Mutants for Inhibition of Angiogenesis

Yun SY, Hong YK, Lee Y, Kim K, Kim HK, Joe YA

  • KMID: 2175025
  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):595-604.
PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor of many solid tumors, promoting vascularization and formation of metastases. In an attempt to generate effective VEGF inhibitors, the authors constructed...
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