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Summarizing the Intentions and Outcomes of JUO 2023 Issue 3

Kwak C

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Role of Radiotherapy in Metastatic Renal Cell Carcinomas: An Evolutionary Journey in a Misunderstood Histological Type

Wee CW, Cho J

Renal cell carcinoma (RCC) has traditionally been considered one of the most radioresistant tumors based on in vitro and clinical studies that utilized a low biologically effective dose. However, recent...
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The Future of Adjuvant Therapy in Renal Cell Carcinoma: Recent Insights and Prospects

Ha H, Lim JH

Renal cell carcinoma (RCC) remains a significant challenge in oncology, prompting thorough investigations into adjuvant treatments aimed at enhancing both survival and quality of life for patients. In this review,...
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Optimal Management of Bacillus Calmette-Guérin–Refractory Non–Muscle-Invasive Bladder Cancer in 2023

Yu J, Sung HH

Bacillus Calmette-Guérin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC) poses a significant clinical challenge, prompting a need for effective treatment options. Although radical cystectomy is a standard approach, it is burdened by...
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Clinical Significance of Rab27a as a Urinary Biomarker in Patients With Bladder Cancer

Ku JY, Huda MN, Hwang EC, Lee CH, Kim KH, Kwon DD, Ha HK

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Early Experience With Pembrolizumab in Bacillus Calmette-Guérin Unresponsive Non–Muscle-Invasive Bladder Cancer

Lee CU, Song W, Kang M, Sung HH, Jeon HG, Seo SI, Jeon SS, Park SH, Jeong BC

Purpose: Radical cystectomy (RC) is recommended for patients with non–muscle-invasive bladder cancer (NMIBC) who are unresponsive to intravesical bacillus Calmette-Guérin (BCG) instillation. However, RC is a very risky treatment, and...
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Influence of Body Composition on the Perioperative and Survival Outcomes of Renal Cell Carcinoma

Nicaise EH, Schmeusser BN, Shah YB, Bilen MA, Ogan K, Master VA

The purpose of this review is to provide an up-to-date understanding of the literature describing the impact of body composition on renal cell carcinoma (RCC) prognosis and outcomes. Although obesity...
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Nonregional Lymph Node Metastasis as a Predictor of Early Progression When Using Androgen Receptor Targeting Agents in Patients With Metastatic Castration-Resistant Prostate Cancer Without Previous Chemotherapy

Kim S, Rho BY, Kang DH, Chung DY

Purpose: In present, the use of androgen receptor targeting agents (ARTA) is one of the standard treatments for metastatic castration-resistant prostate cancer (mCRPC) without previous chemotherapy. However, some patients may...
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Negative Delta-Prostate-Specific Antigen Time Ratio as Potential New Marker of Progression-Free Survival in Castration-Resistant Prostate Cancer Patients Treated With First-Line Enzalutamide or Docetaxel

Kim TH, Choo SH, Shim KH, Kim SI

Purpose: We propose a new potential marker of progression-free survival (PFS) called negative delta-prostate-specific antigen (PSA) time ratio (NDPSATR) and compare it with conventional PSA response, defined as PSA decline...
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Predictive Factors of Abiraterone Response in Patients With High-Risk Metastatic Hormone-Sensitive Prostate Cancer

Cho J, Suh J, You D, Jeong IG, Hong JH, Ahn H, Lim B

Purpose: This study aimed to identify predictive factors for the response to abiraterone in patients with high-risk metastatic hormone-sensitive prostate cancer (mHSPC). Materials and Methods: This study analyzed the clinical characteristics...
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Clinical Outcomes of Patients With Variant Histology of Urothelial Carcinoma After Radical Cystectomy

Lee DB, Kim JY, Lee YH, Song WH, Lee SS, Park SW, Nam JK

Purpose: The efficacy of standard chemotherapy or radical cystectomy in patients who have urothelial tumors with variant histology (VH) is very limited in terms of their prognosis. This study aimed...
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Preoperative Renal Artery Embolization Before Radical Nephrectomy for Nonmetastatic Renal Cell Carcinoma: A Propensity Score Matched Analysis

Noh J, Song SH, Jung G, Lee S, Hong SK, Byun SS, Kim JK

Purpose: This study investigated the effects of preoperative renal artery embolization (PRAE) before radical nephrectomy (RN) for advanced nonmetastatic renal cell carcinoma (RCC) on perioperative and oncologic outcomes. Materials and Methods:...
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