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Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity

Soedono S, Julietta V, Nawaz H, Cho KW

Adipose tissue macrophages (ATMs) are key regulators of adipose tissue (AT) inflammation and insulin resistance in obesity, and the traditional M1/M2 characterization of ATMs is inadequate for capturing their diversity...
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Progressive Impairment of Cardiac Autonomic Regulation as the Number of Metabolic Syndrome Components Increases

Lucini D, Giovanelli L, Malacarne M, Bernardelli G, Ardigò A, Gatzemeier W, Solaro N

Background: Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular diseases. Compelling evidence supports the key role of dysfunction in the autonomic nervous system in that association, as...
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Gene-Environment Interactions Significantly Alter the Obesity Risk of SH2B1 rs7498665 Carriers

Chermon D, Birk R

Background: Src homology 2 B adaptor protein 1 (SH2B1) gene and variants have been found to be associated with common obesity. We aimed to investigate the association between the common...
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Associations between Global Diet Quality Score and Risk of Metabolic Syndrome and Its Components: Tehran Lipid and Glucose Study

Hosseini-Esfahani F, Daei S, Ildarabadi A, Koochakpoor G, Mirmiran P, Azizi F

Background: Various food quality indicators have been proposed as tools for predicting metabolic syndrome (MetS). This study investigated the association between global diet quality score (GDQS) and the risks of...
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Associations of the PPARα and Lipoprotein Lipase Enzyme Gene Polymorphisms with Dyslipidemia in Obese and Non-obese Males

Al-Samawi RI, Al-Kashwan TA, Algenabi AHA

Background: Peroxisome proliferator-activated receptor α (PPARα) is a nuclear transcription factor responsible for gene expression, particularly those associated with lipid metabolism. The lipoprotein lipase enzyme (LPL) is considered a key...
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Effect of Whole-Body Electrical Muscle Stimulation Training on Inflammatory and Anti-inflammatory Cytokines in Overweight Men

Salehi MRP, Reisi J, Marandi SM, Abdollahi M

Background: The aim of this study was to investigate the effects of whole-body electrical muscle stimulation (WB-EMS) training on inflammatory and anti-inflammatory cytokines in overweight men. Methods: We divided 30 participants...
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Combination of Metformin and Epigallocatechin-3- Gallate Lowers Cortisol, 11β-Hydroxysteroid Dehydrogenase Type 1, and Blood Glucose Levels in Sprague Dawley Rats with Obesity and Diabetes

Atsarina DM, Widyastiti NS, Muniroh M, Susilaningsih N, Maharani N

Background: The combined effects of metformin and epigallocatechin-3-gallate (EGCG) on cortisol, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and blood glucose levels have not been investigated. This study evaluated the effectiveness of...
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Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Index for Classification of Patients with Steatotic Liver Disease

Roy A, De A, Kulkarni AV, Jajodia S, Goenka U, Tewari A, Sonthalia N, Goenka MK

Background: Steatotic liver disease (SLD) encompasses metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (AALD) at extremes as well as an overlap group termed MASLD with increased alcohol...
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