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Obesity and Polycystic Ovary Syndrome

Kim JJ

The core pathophysiology of polycystic ovary syndrome involves an overproduction of androgens primarily originating from ovarian thecal cells. Two major external triggers promote androgen overproduction in the ovaries: the increased...
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Understanding Adipose Tissue Dysfunction

Blüher M

Diseases affecting adipose tissue (AT) function include obesity, lipodystrophy, and lipedema, among others. Both a lack of and excess AT are associated with increased risk for developing diseases including type 2...
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Weightism in Asia: A Narrative Review and Implications for Practice

Mathialagan S, Lau PL

Weightism, also known as weight-related discrimination, is pervasive and believed to be one of the socially accepted types of discrimination in Asia. Weightism is pervasive, impactful, and has significant repercussions...
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The Effects of Tirzepatide on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mahar MU, Mahmud O, Ahmed S, Qureshi SA, Kakar WG, Fatima SS

Background: Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP)-glucagon-like peptide 1 (GLP-1) receptor agonist being evaluated for the treatment of various metabolic disorders. We performed a meta-analysis of randomized...
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Growth Hormone, Hypothalamic Inflammation, and Aging

Velloso LA, Jr. JD

While inflammation is a crucial response in injury repair and tissue regeneration, chronic inflammation is a prevalent feature in various chronic, non-communicable diseases such as obesity, diabetes, and cancer and...
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Relationships of Thickness of Perirenal Fat with Urinary Levels of MCP-1 and NGAL in Patients with Hypertension

Bragina A, Rodionova Y, Osadchiy K, Bayutina D, Vasilchenko MK, Fomin A, Podzolkov V

Background: We conducted a study to determine the relationships between perirenal fat (PRF) thickness and urinary levels of monocyte chemoattractant protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with...
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Association between Body Fat Distribution and Nonalcoholic Fatty Liver Disease/Fibrosis Based on Race/Ethnicity

Kim D, Cholankeril G, Ahmed A

Background: Body fat distribution may impact nonalcoholic fatty liver disease (NAFLD) and significant fibrosis differently according to race/ethnicity. We determined the relationship between body fat distribution and NAFLD/ significant fibrosis...
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Anthropometric Changes in Female Participants Enrolled in a Combined Aerobic and Resistance Training Program for Longer than 1 Year: A Cohort Study

Lim JS, Hwang HJ, Eum YH, Kim HJ, Cheung B, Oh HJ, Oh B

Background: To analyze the anthropometric changes in women who had participated in a combined resistance and aerobic training program for more than a year and to determine the effect of...
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Predictors of Successful Weight Loss in Extremely Obese Individuals Undergoing Roux-en-Y Gastric Bypass Surgery

Moreira SHC, Alvarez-Leite JI, Souza RP, Resmini GC, Resende CMM, Marco Ld, Bastos-Rodrigues L

Background: Roux-en-Y gastric bypass (RYGB) is a standard treatment for severe obesity, but some patients do not achieve the expected success in weight loss. The aim of this study was...
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