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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by abdominal pain and disordered bowel habits. The etiology of IBS is multifactorial, including abnormal gut-brain interactions, visceral...

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7 Relationship Between Intestinal Slow-waves, Spike-bursts, and Motility, as Defined Through High-resolution Electrical and Video Mapping

Kuruppu S, Cheng LK, Avci R, Angeli-Gordon TR, Paskaranandavadivel N

KMID: 2534325
J Neurogastroenterol Motil.
2022 Oct;28(4):664-677.
doi: 10.5056/jnm21183

Background/Aims High-resolution extracellular mapping has improved our understanding of bioelectric slow-wave and spike-burst activity in the small intestine. The spatiotemporal correlation of electrophysiology and motility patterns is of critical interest to...

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8 Concise Review: Applicability of High-resolution Manometry in Gastroesophageal Reflux Disease

Jandee S, Keeratichananont S, Tack J, Vanuytsel T

KMID: 2534312
J Neurogastroenterol Motil.
2022 Oct;28(4):531-539.
doi: 10.5056/jnm22082

Manometry, particularly high-resolution manometry is the preferred diagnostic tool used to evaluate esophageal motor function. This investigation is strongly indicated in the setting of dysphagia, but is also useful in...

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9 Bile Acid and Gut Microbiota in Irritable Bowel Syndrome

Min YW, Rezaie A, Pimentel M

KMID: 2534314
J Neurogastroenterol Motil.
2022 Oct;28(4):549-561.
doi: 10.5056/jnm22129

Gut microbiota and their metabolites like bile acid (BA) have been investigated as causes of irritable bowel syndrome (IBS) symptoms. Primary BAs are synthesized and conjugated in the liver and released...

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10 Type of Rectal Barostat Protocol Affects Classification of Hypersensitivity and Prediction of Symptom Severity in Irritable Bowel Syndrome

Josefsson A, Törnblom H, Simrén M

KMID: 2534322
J Neurogastroenterol Motil.
2022 Oct;28(4):630-641.
doi: 10.5056/jnm21214

Background/Aims Visceral hypersensitivity is an important pathophysiologic mechanism in irritable bowel syndrome (IBS). We compared 2 barostat distension protocols and their ability to distinguish between IBS patients and healthy controls, identify...

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11 Clinical Implications of the Gastroesophageal Reflux Disease Questionnaire and Reflux Symptom Index in Patients With Suspected Laryngopharyngeal Reflux Symptoms

Kim YD, Shin CM, Jeong WJ, Kim YJ, Yoon H, Park YS, Kim N, Lee DH

KMID: 2534319
J Neurogastroenterol Motil.
2022 Oct;28(4):599-607.
doi: 10.5056/jnm21235

Background/Aims To evaluate the usefulness of gastroesophageal reflux disease questionnaire (GerdQ) and reflux symptom index (RSI) for diagnosis of gastroesophageal reflux disease (GERD) in patients with suspected laryngopharyngeal reflux (LPR) symptoms...

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12 Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index Could Identify Gastroesophageal Reflux Disease but pH-Impedance Metrics Alone Might Not Correlate With Proton Pump Inhibitor Response in Chinese Patients With Typical Reflux Symptoms

Wang D, Duan C, Zhang X, Xu J, Hou X, Xiang X

KMID: 2534317
J Neurogastroenterol Motil.
2022 Oct;28(4):580-588.
doi: 10.5056/jnm21156

Background/Aims Lyon consensus differentiates acid exposure time (AET) as physiological, borderline, and pathological. Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave index (PSPWi) are believed to increase diagnostic yield...

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13 Estimating Probability for Esophageal Obstruction: A Diagnostic Decision Support Tool Applying Machine Learning to Functional Lumen Imaging Probe Panometry

Schauer JM, Kou W, Prescott JE, Kahrilas PJ, Pandolfino JE, Carlson DA

KMID: 2534316
J Neurogastroenterol Motil.
2022 Oct;28(4):572-579.
doi: 10.5056/jnm21239

Background/Aims This study aimed to develop a diagnostic tool using machine learning to apply functional luminal imaging probe (FLIP) panometry data to determine the probability of esophagogastric junction (EGJ) obstruction as...

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14 Inflammation and Impaired Gut Physiology in Post-operative Ileus: Mechanisms and the Treatment Options

Hussain Z, Park H

KMID: 2534311
J Neurogastroenterol Motil.
2022 Oct;28(4):517-530.
doi: 10.5056/jnm22100

Post-operative ileus (POI) is the transient cessation of coordinated gastrointestinal motility after abdominal surgical intervention. It decreases quality of life, prolongs length of hospital stay, and increases socioeconomic costs. The...

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15 Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility

Lei WY, Liang SW, Omari T, Chang WC, Wong MW, Hung JS, Yi CH, Liu TT, Lin L, Gyawali CP, Chen CL

KMID: 2534318
J Neurogastroenterol Motil.
2022 Oct;28(4):589-598.
doi: 10.5056/jnm21189

Background/Aims Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during...

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16 Distribution and Function of Platelet-derived Growth Factor Receptor Alpha-positive Cells and Purinergic Neurotransmission in the Human Colon: Is It Different Between the Right and Left Colon?

Lee Ky, Sung TS, Koh BH, Ryoo SB, Chun JN, Kim SH, Park KJ, So I

KMID: 2534326
J Neurogastroenterol Motil.
2022 Oct;28(4):678-692.
doi: 10.5056/jnm21117

Background/Aims Platelet-derived growth factor receptor alpha-positive (PDGFRα + ) cells function in the purinergic regulation of gastrointestinal motility, and purines are reportedly inhibitory neurotransmitters in the enteric nervous system. We explore...

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17 Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome

Kim JH, Lee SW, Kwon Y, Ha EK, An J, Cha HR, Jeong SJ, Han MY

KMID: 2534321
J Neurogastroenterol Motil.
2022 Oct;28(4):618-629.
doi: 10.5056/jnm21181

Background/Aims Little is known about the association between infantile colic and the later onset of irritable bowel syndrome (IBS). Methods This study examined all 917 707 children who were born in Korea between...

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18 Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial

Shin SY, Park S, Moon JM, Kim K, Kim JW, Chun J, Lee TH, Choi CH, The Microbiome Research Group of the Korean Society for Neurogastroenterology and Motility

KMID: 2534323
J Neurogastroenterol Motil.
2022 Oct;28(4):642-654.
doi: 10.5056/jnm21202

Background/Aims We aim to evaluate the differences in the microbiome of responders and non-responders, as well as predict the response to probiotic therapy, based on fecal microbiome data in patients with...

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19 Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model

Sugino S, Inoue K, Kobayashi R, Hirose R, Doi T, Harusato A, Dohi O, Yoshida N, Uchiyama K, Ishikawa T, Takagi T, Yasuda H, Konishi H, Hirai Y, Mizushima K, Naito Y, Tsuji T, Okuda T, Kagawa K, Tominaga M, Itoh Y

KMID: 2534327
J Neurogastroenterol Motil.
2022 Oct;28(4):693-705.
doi: 10.5056/jnm21198

Background/Aims Several studies have assessed the effect of cool temperature on colonic peristalsis. Transient receptor potential melastatin 8 (TRPM8) is a temperature-sensitive ion channel activated by mild cooling expressed in the...

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20 Predicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume

Seo M, Yoon J, Jung KW, Joo S, Lee J, Choi KM, Lee HJ, Yoon IJ, Noh W, Seo SY, Kim DY, Hwang SW, Park SH, Yang DH, Ye BD, Byeon JS, Yang SK, Myung SJ

KMID: 2534320
J Neurogastroenterol Motil.
2022 Oct;28(4):608-617.
doi: 10.5056/jnm21137

Background/Aims Biofeedback therapy is widely used to treat patients with chronic constipation, especially those with dyssynergic defecation. Yet, the utility of high-resolution manometry with novel parameters in the prediction of biofeedback...

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