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Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of...

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6 Elevated Intrabolus Pressure Predicts Abnormal Timed Barium Esophagram in Esophagogastric Junction Outflow Obstruction

Hoscheit M, Gabbard S

KMID: 2460481
J Neurogastroenterol Motil.
2019 Oct;25(4):521-524.
doi: 10.5056/jnm19025

BACKGROUND/AIMS: Timed barium esophagram (TBE) is used the classification of esophageal motility disorders and assessing esophageal function. Currently, there are no published studies examining the relationship between high-resolution manometry and...

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7 Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats

Yang Y, Yu H, Babygirija R, Shi B, Sun W, Zheng X, Zheng J

KMID: 2460490
J Neurogastroenterol Motil.
2019 Oct;25(4):611-622.
doi: 10.5056/jnm19065

BACKGROUND/AIMS: Gastrointestinal (GI) symptoms may develop when we fail to adapt to various stressors of our daily life. Central oxytocin (OXT) can counteract the biological actions of corticotropin-releasing factor (CRF),...

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8 Pyridostigmine in Pediatric Intestinal Pseudo-obstruction: Case Report of a 2-year Old Girl and Literature Review

Di Nardo G, Viscogliosi F, Esposito F, Stanghellini V, Villa MP, Parisi P, Morlando A, CalÃ² G, De Giorgio R

KMID: 2460479
J Neurogastroenterol Motil.
2019 Oct;25(4):508-514.
doi: 10.5056/jnm19078

Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes. The diagnosis is...

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9 Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone

Olesen AE, GrÃ¸nlund , Mark EB, Krogh K, FrÃ¸kjÃ¦r , Drewes AM

KMID: 2460489
J Neurogastroenterol Motil.
2019 Oct;25(4):602-610.
doi: 10.5056/jnm18079

BACKGROUND/AIMS: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed...

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10 Diagnosis and Management of Functional Chest Pain in the Rome IV Era

Fass R, Shibli F, Tawil J

KMID: 2460477
J Neurogastroenterol Motil.
2019 Oct;25(4):487-498.
doi: 10.5056/jnm19146

Functional chest pain accounts for about a third of the patients with noncardiac chest pain. It is a very common functional esophageal disorder that remains even today a management challenge...

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11 What Is Appropriate Upper Endoscopic Interval Among Dyspeptic Patients With Previously Normal Endoscopy? A Multicenter Study With Bayesian Change Point Analysis

Kim JW, Jung KW, Kwon JG, Lee JB, Park JK, Bang KB, Tae CH, Oh JH

KMID: 2460484
J Neurogastroenterol Motil.
2019 Oct;25(4):544-550.
doi: 10.5056/jnm19063

BACKGROUND/AIMS: Appropriate interval for performing follow-up endoscopy among dyspeptic patients without abnormal findings on previous endoscopy is unclear. We analyzed the multicenter-collected data from the Korean Society of Neurogastroenterology and...

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12 Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells

Wang Q, Zang J, Huang X, Lu H, Xu W, Chen J

KMID: 2460488
J Neurogastroenterol Motil.
2019 Oct;25(4):589-601.
doi: 10.5056/jnm19136

BACKGROUND/AIMS: Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO)...

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13 Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients

Wuestenberghs F, Juge M, Melchior C, Desprez C, Leroi AM, Gourcerol

KMID: 2460483
J Neurogastroenterol Motil.
2019 Oct;25(4):534-543.
doi: 10.5056/jnm19060

BACKGROUND/AIMS: Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated...

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14 Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn

Sun YM, Gao Y, Gao F

KMID: 2460480
J Neurogastroenterol Motil.
2019 Oct;25(4):515-520.
doi: 10.5056/jnm19056

BACKGROUND/AIMS: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH...

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15 Prevalence and Severity of Fecal Incontinence in Veterans

Hosmer AE, Saini SD, Menees SB

KMID: 2460487
J Neurogastroenterol Motil.
2019 Oct;25(4):576-588.
doi: 10.5056/jnm17134

BACKGROUND/AIMS: Fecal incontinence (FI) is a common complaint that increases in prevalence with age. Our aim was to determine the prevalence of FI and assess its severity by self-report in...

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16 A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

KMID: 2460486
J Neurogastroenterol Motil.
2019 Oct;25(4):563-575.
doi: 10.5056/jnm18194

BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...

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17 Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study

Burr RL, Gu H, Cain K, Djukovic D, Zhang X, Han C, Callan N, Raftery D, Heitkemper M

KMID: 2460485
J Neurogastroenterol Motil.
2019 Oct;25(4):551-562.
doi: 10.5056/jnm19042

BACKGROUND/AIMS: Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women...

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18 An Increasing Trend of Eosinophilic Esophagitis in Korea and the Clinical Implication of the Biomarkers to Determine Disease Activity and Treatment Response in Eosinophilic Esophagitis

Kim GH, Park YS, Jung KW, Kim M, Na HK, Ahn JY, Lee JH, Kim DH, Choi KD, Song HJ, Lee GH, Dellon ES, Jung HY

KMID: 2460482
J Neurogastroenterol Motil.
2019 Oct;25(4):525-533.
doi: 10.5056/jnm19066

BACKGROUND/AIMS: The epidemiology and pathogenesis of eosinophilic esophagitis (EoE) remain unclear in Asian countries. We investigated clinicopathological characteristics and diagnostic trends of EoE, and evaluated 3 tissue biomarkers for correlation...

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