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Hepatocellular carcinoma in Korea: an analysis of the 2016-2018 Korean Nationwide Cancer Registry

An J, Chang Y, Choi GH, Sohn W, Song JE, Shin H, Yoon JH, Yoon JS, Jang HY, Cho EJ, Han JW, Hong SK, Cho JY, Jung KW, Park EH, Kim E, Kim BH

Backgrounds/Aims: Hepatocellular carcinoma (HCC) is the sixth most common cancer and second leading cause of cancer-related deaths in South Korea. This study evaluated the characteristics of Korean patients newly diagnosed...
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Identification of new biomarkers of hepatic cancer stem cells through proteomic profiling

Choi SH, Lee HY, Yun SH, Jang SJ, Kim SU, Park JY, Ahn SH, Kim DY

Backgrounds/Aims: In hepatocellular carcinoma (HCC), which exhibits high mortality and recurrence rates globally, the traits of cancer stem cells (CSCs) that significantly influence recurrence and metastasis are not well understood....
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Epidemiology and genomic features of biliary tract cancer and its unique features in Korea

Woo S, Kim Y, Hwang S, Chon HJ

Biliary tract cancer (BTC) is a rare but highly aggressive malignancy that includes intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma, and gallbladder cancer (GBC). While BTC has a low global incidence, its...
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Microwave ablation vs. liver resection for patients with hepatocellular carcinomas

Gu H, Seo Y, Chung DJ, Paik KY, Yoon SK, Lim J

Backgrounds/Aims: Microwave ablation (MWA) is an emerging ablative therapy that surpasses previous methods by achieving higher temperatures and creating larger ablation zones within shorter periods. This study compared the therapeutic...
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A concise review of updated global guidelines for the management of hepatocellular carcinoma: 2017-2024

Shin H, Yu SJ

Many guidelines for hepatocellular carcinoma (HCC) have been published and are regularly updated worldwide. HCC management involves a broad range of treatment options and requires multidisciplinary care, resulting in significant...
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Molecular and immune landscape of hepatocellular carcinoma for therapeutic development

Suzuki H, Mishra S, Paul S, Hoshida Y

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with an estimated 750,000 deaths in 2022. Recent emergence of molecular targeted agents and immune checkpoint inhibitors and their...
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Insights into hepatocellular adenomas in Asia: molecular subtypes, clinical characteristics, imaging features, and hepatocellular carcinoma risks

Heo S, Song IH, Reizine E, Ronot M, Nault JC, Kim HY, Choi SH, Kim SY

Hepatocellular adenomas (HCAs) are benign monoclonal liver tumors. Advances in molecular studies have led to the identification of distinct subtypes of HCA with unique pathways, clinical characteristics, and complication risks,...
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Management of hepatocellular carcinoma in elderly and adolescent/young adult populations

Lee HA

Hepatocellular carcinoma (HCC) presents unique challenges in both the elderly and adolescent/young adult (AYA) populations, requiring distinct management approaches. Recent epidemiological data show an increasing incidence of HCC in both...
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Recent advances and issues in imaging modalities for hepatocellular carcinoma surveillance

Lee DH

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Early detection via surveillance plays a crucial role in enabling curative treatment and improving survival rates. Since the initial...
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Synergistic effects of L-arginine and argininosuccinate synthetase 1 in inducing apoptosis in hepatocellular carcinoma

Kim JS, Choi WM, Kim HI, Chung SW, Choi J, Lee D, Kim KM

Backgrounds/Aims: Hepatocellular carcinoma (HCC) is a malignant cancer with an increasing incidence worldwide. Although numerous efforts have been made to identify effective therapies for HCC, current strategies have limitations. We...
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Antitumor role of L-arginine and argininosuccinate synthetase 1 in hepatocellular carcinoma: direct and immunological mechanisms

Eun HS

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Correspondence to editorial on “Evolving trends in epidemiology, etiology, and treatment patterns for hepatocellular carcinoma in South Korea”

Han JW, Kim BH

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Enhanced radiofrequency ablation for recurrent hepatocellular carcinoma post-transarterial chemoembolization: a prospective study utilizing twin internally cooled-perfusion electrodes

Hwang S, Kim JH, Park SJ, Yu SJ, Kim YJ, Yoon JH, Lee JM

Backgrounds/Aims: Radiofrequency ablation (RFA) is widely employed for managing recurrent hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE). However, local tumor progression (LTP) after treatment remains a significant challenge. This study...
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Evolving trends in epidemiology, etiology, and treatment patterns for hepatocellular carcinoma in South Korea

Hwang SY, Yang JD

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Durable complete response after discontinuation of atezolizumab-bevacizumab therapy in patients with hepatocellular carcinoma with portal vein tumor thrombosis: the first report

Kumar P, Krishna P, Maidur R, Chandrashekhar N, Raghavaiah S

Hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is associated with a dismal prognosis. Atezolizumab plus bevacizumab (atezo-bev) is the recommended palliative treatment, and approximately 10% of the patients...
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