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Extracellular Vesicles as Mediators in Atherosclerotic Cardiovascular Disease

Zisser L, Binder CJ

Atherosclerosis is a chronic inflammatory disease of the arterial intima, characterized by accumulation of lipoproteins and accompanying inflammation, leading to the formation of plaques that eventually trigger occlusive thrombotic events,...
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Emerging Circulating Biomarkers for Enhanced Cardiovascular Risk Prediction

Lee DY

Cardiovascular disease (CVD) continues to be the primary cause of mortality worldwide, underscoring the importance of identifying additional cardiovascular risk factors. The consensus is that lipid levels alone do not...
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2024 KSoLA Consensus on Secondary Dyslipidemia

Won H, Bae JH, Lim H, Kang M, Kim M, Lee SH, on behalf of the Clinical Practice Guidelines Committee, Korean Society of Lipid and Atherosclerosis (KSoLA)

Elevated blood cholesterol and triglyceride levels induced by secondary causes are frequently observed. The identification and appropriate handling of these causes are essential for secondary dyslipidemia treatment. Major secondary causes...
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Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review

Wai KW, Low LE, Goh BH, Yap WH

Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional factor that maintains intracellular redox equilibrium, modulates the expression of antioxidant genes, scavenger receptors, and cholesterol efflux transporters, all of which...
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Targeting Mitochondrial Dysfunction for the Prevention and Treatment of Metabolic Disease by Bioactive Food Components

Kim MB, Lee J, Lee JY

Dysfunctional mitochondria have been linked to the pathogenesis of obesity-associated metabolic diseases. Excessive energy intake impairs mitochondrial biogenesis and function, decreasing adenosine-5’-triphosphate production and negatively impacting metabolically active tissues such...
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Mendelian Randomization Studies in Atherosclerotic Cardiovascular Diseases

Ko DS, Kim YH

This review aimed to highlight the pivotal role of Mendelian randomization (MR) in advancing atherosclerotic cardiovascular disease (ASCVD) research—a field often hindered by the complexities and limitations of traditional studies....
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Adherence to Dietary Patterns and Cardiovascular Disease Risk: A CrossSectional Study of Total Carotid Plaque Area in Argentina

Carrillo MN, Garribia M, Armando L, Adeoye AO, Garcia NH, Muñoz SE

Objective: Assessing subclinical atherosclerosis (sAT) is crucial for preventing cardiovascular disease. The Mediterranean diet is considered the gold standard for cardiovascular protection, but cultural and economic barriers can hinder adherence...
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Comparison of Multiple Equations for Low-Density Lipoprotein Cholesterol Calculation Against the Direct Homogeneous Method

Alsadig RE, Morsi AN

Objective: Several equations have been proposed as alternatives for the reference method of measuring low-density lipoprotein cholesterol (LDL-C). This study aimed to evaluate these alternatives in comparison to the homogeneous...
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Therapeutic Vaccines and Nucleic Acid Drugs for Cardiovascular Disease

Nakagami H, Hayashi H, Morishita R

To combat the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), novel vaccine modalities, such as messenger RNA vaccines, were rapidly developed and have shown high efficacy. This new...
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The Effects of Anti-thyroid Drugs on Lipoproteins and Insulin Resistance in Graves’ Disease: A Randomized Clinical Trial

Wisnu W, Alwi I, Nafrialdi N, Pemayun TGD, Pantoro NI, Wijaya CN, Tahapary DL, Tarigan TJE, Subekti I

Objective: Graves’ disease (GD) is characterized by thyroid overactivity. Anti-thyroid drugs (ATDs), such as propylthiouracil (PTU) and methimazole (MMI), are commonly used for GD treatment, and studies have suggested a...
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