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New Approach in the Treatment of Epilepsy: Efficacy of New Antiepileptic Drugs

Lee DH

  • KMID: 2334566
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):175-183.
To consider current concepts of epilepsy further, the brief review begins with a discussion of what is epilepsy, discribes multifactorial nature of epileptic disorders, and ends with a presentation of...
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Augmentation Strategies in Obsessive Compulsive Disorder

Lee C

  • KMID: 2334564
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):162-165.
The serotonin reuptake inhibitors(SRIs) and the serotonin selective reuptake inhibitors(SSRIs) are considered the first choice agents for pharmacologic treatment of obsessive-compulsive disordr(OCD). However, many patients with OCD experience little or...
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Prefrontal Cortex and Schizophrenia

Chung YC, Eun HB

  • KMID: 2334567
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):184-196.
With a rapid development of neuroscience, the theories related to the pathophysiology of schizophrenia have been changed a lot from a simple hyperdopaminergic one to the various complicated ones. Among...
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Treatment Strategy for Antipsychotic-Induced Side Effects

Yoon JS, Shin IS

  • KMID: 2334565
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):166-174.
While the therapeutic efficacy of antipsychotic drugs is not in doubt, a variety of undesirable side effects are common. They can be a disincentive to good compliance with treatment, resulting...
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An Association Study of COMT Gene Polymorphism with Korean Schizophrenics

Song ES, Chai YG, Yang BH, Park KK, Oh DY, Kim GS, Lee YS, An ES, Kim JW, Choi IG

  • KMID: 2334569
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):210-214.
An association study with Korean schizophrenic patients(N=84) and normal controls(N=87) was performed to find the relationship between catechol-o-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain reaction-restriction fragment length polymorphism. When...
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Drug Augmentation strategies in the Treatment of Mood Disdorder

  • KMID: 2334563
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):155-161.
Mood disorder is a medical illness resulting from the disorder of CNS neurotransmission and its principal therapeutic tool is pharmacotherapy. Psychotherapeutic drugs for mood disorder have some clinical limitations which...
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The Relation of Antipsychotic Drug Induced-Acute Dystonia and Serum Iron Level

Lee DJ, Park IJ, Kwon YJ, Jeong HY, Han SH

  • KMID: 2334575
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):248-252.
OBJECT: This study was performed in order to examine the correlation between acute neuroleptic-induced dystonic reactions and serum iron level. METHOD: Serum iron levels were measured in psychiatric inpatients who had...
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Augmentation Strategies for the Treatment of Schizophrenia

Chung YK

  • KMID: 2334562
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):149-154.
Antipsychotic drugs(APDs) have been effective to alleviate psychotic symptoms of schizophrenia. However, some schizophrenic patients do not respond to APDs. In addition to psychotic symptoms of schizophrenia, negative symptoms, excitement,...
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Diurnal and insulin-Induced Variations of Plasma Homovanillic Acid Concentrations

Jung KC, Kim BH, Hahn KH

  • KMID: 2334574
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):243-247.
The authors tried to confirm the significant changes of plasma homovanillic acid(HVA) concentration after insulin administration in comparison with those of usual diurnal variation in the same subjects. Male patients...
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Neuroscience of Eating Behavior: Focusing on Intake

Lee YH

  • KMID: 2334568
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):197-209.
In mordern society, nutritional and appetite disorders occur in epidemic proportions and are serious health harzards. Obesity and diabetes affect over 30% of American population, while eating disorders, such as...
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Association between Schizophrenia and the T102C Polymorphism of the 5-HT2A

Lee MS, Nam JW, Kwak DI

  • KMID: 2334570
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):215-218.
The 5-HT2A receptor is of great interest for research into schizophrenia and psychopharmacology in light of the observation that schizophrenic patients has 5-HT cortical-subcortical imbalance and atypical antipsychotic clozpine has...
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Cytosine Arabinoside-Induced PC12 Cell Death Pathway

Yang BG, Chai YG, Yang BH

  • KMID: 2334571
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):219-226.
Cytosine arabinoside(AraC) inhibits DNA synthesis and beta-DNA polymerase, an enzyme involved in DNA repair. This a potent antimitotic agent, is clinically used as an anticancer drug with side effect of...
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The Relationship between Lipid Peroxidation of Red Blood Cell Membrane, and Mean Corpuscular Volume and Liver Enzyme Markers in Alcohol Dependence Patients

Jeong SY, Choi IG, Suh GH, Kang HJ

  • KMID: 2334573
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):235-242.
OBJECTIVES: Alcohol-induced oxidative stress has been known to injure various tissues or organs. This stress is related with free radicals which are produced as the result of long-term alcohol consumption....
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The Effects of Chronic Carbamazepine Administration on Protein Kinase A and Protein Kinase C Activities in Rat Brain

Rheem DW, Kim L, Suh KY

  • KMID: 2334572
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):227-234.
OBJECTIVE: Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning...
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Norepinephrine and Serotonin in the Patients with Psychogenic Impotence

Kim JS, Jung IK, Ryu SH, Moon DG, Kim JJ

  • KMID: 2334578
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):278-282.
Various neurotransmitters have been proposed as possible mediators of penile erection. Especially, norepinephrine and serotonin might have a important role in sexual arousal and penile erection. And it could be...
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A Study for Dose-Reduction of Antipsychotics in Chronic Schizophrenics

Hwang TY, Kim HS, Lee MS

  • KMID: 2334577
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):263-277.
Conventional high-dose antipsychotics tend to result in more side effects, negative symptoms and dysphoria, and at the same time lower the cognitive function which is already impaired in most schizophrenics....
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The Effect of Risperidone on Serum Prolactin Concentrations

Cheon JS, Cho W, Oh BH

  • KMID: 2334576
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):253-262.
OBJECTIVES: Risperidone, an atypical antipsychitics which blocks both dopaminergic and serotonergic receptors, have a good response to the negative symptoms as well as positive symptoms, and improve cognitive dysfunction of...
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