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Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT)

Kobayashi Y, Shimada M, Tamate M, Cho HW, Zhu J, Chou HH, Kajiyama H, Okamoto A, Aoki D, Kang S, Lee JW, Kim JW, Kim JH, Lin Z, Lin J, Wu X, Lai HC, Chang TC, Lai CH, Kim YM, Enomoto T

Ovarian cancer, notable for its severe prognosis among gynecologic cancers, has seen substantial progress in treatment approaches recently. Enhanced protocols in chemotherapy and the introduction of poly (ADP-ribose) polymerase (PARP)...
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Hormone replacement therapy in gynecological cancer survivors and BRCA mutation carriers: a MITO group survey

Palaia I, Caruso G, Donato VD, Turetta C, Savarese A, Perniola G, Gallo R, Giannini A, Salutari V, Bogani G, Tomao F, Giannarelli D, Gentile G, Musella A, Muzii L, Pignata S, obotMg

Objective: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective...
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Prognostic factors of adult granulosa cell tumors of the ovary: a Turkish retrospective multicenter study

Oktar O, Korkmaz V, Tokalıoğlu A, Öztürk , Erdoğan , Uçar Y, Koca Yıldırım HE, Hanedan C, Kılıç F, Ersak B, Yalçın N, Özmen F, Kahraman A, Esen SA, Baş S, Özdaş ED, Selçuk , Uçar G, Koçak , Çakır C, Koç S, Kılıç , Cömert GK, Üreyen I, Toptaş T, Narin MA, Taşçı T, Taşkın S, Boran N, Sancı M, Köş FT, Tekin , Üstün YE, Ortaç F, Turan T

Objective: To define the clinical, histopathological features and the prognostic factors affecting survival in patients with adult granulosa cell tumors of the ovary (AGCT). Methods: A 322 patients whose final pathologic...
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Enrichment for the POLE mutated against p53 wild subtype using clinicopathologic factors and cyclin B1 immunohistochemistry in endometrial cancer

Parulekar M, Kim H, Kim K, Ala A

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Revisiting the meaning of Trousseau sign and syndrome

Yale SH, Tekiner H, Yale ES

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Author's reply to: Revisiting the meaning of Trousseau sign and syndrome

Kanno M, Yunokawa M, Fusegi A, Abe A, Nomura H, Kanao H

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Response to: Author's reply to: Effect of adjuvant treatment on survival in 2023 FIGO stage IIC endometrial cancer

Akgor U, Ozgul N, Ayhan A

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Effect of adjuvant treatment on survival in 2023 FIGO stage IIC endometrial cancer

Akgor U

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Author's reply to: Effect of adjuvant treatment on survival in 2023 FIGO stage IIC endometrial cancer

Lee YY, Chen YL, Lai YL

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Intraoperative frozen section pathology of vaginal margin in radical hysterectomy on the prognosis and quality of life for patients with IB2–IIA2 cervical cancer: study protocol for a multicenter randomized controlled trial

Liu Y, Xin W, Wang P, Ji M, Guo X, Ouyang Y, Zhao D, Hua K

Background: Several risk factors have been identified that compromise the treatment outcome in patients with early-to-mid-stage cervical cancer (CC) who are primarily treated with radical surgery. However, there is no...
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Confirmation of the utility of the CA-125 elimination rate (KELIM) as an indicator of the chemosensitivity in advanced-stage ovarian cancer in a “real-life setting”

Wagensveld Lv, Colomban O, van der Aa MA, Freyer G, Sonke GS, Kruitwagen RF, You B

Objective: The modeled CA-125 ELIMination rate constant K (KELIM) has been validated as a marker of response to chemotherapy in >12,000 patients with advanced epithelial ovarian carcinoma (EOC) treated in...
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Can surgery boost the survival benefit of chemoradiotherapy in T1b1-T2a1 stage cervical cancer with lymph node metastasis? A population-based study

Wang Y, Lyu Y, Che X, Li J, Feng W

Objective: This study aimed to determine whether surgery followed by adjuvant chemoradiotherapy has superior survival outcomes for node-positive patients with T1b1-T2a1 stage cervical cancer compared with those who undergo chemoradiation. Methods:...
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Development and validation of a novel scoring system to predict the risk of uterine perforation during intracavitary brachytherapy for cervical cancer

Parvath ESM, John NO, Sathyamurthy A, Ramireddy JK, Ram TS

Objective: To develop and validate a novel scoring system for predicting the risk of uterine perforation during brachytherapy (BT) in cervical cancer patients and to stratify patients based on this...
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Trends in the incidence and survival outcomes of endometrial cancer in Korea: a nationwide population-based cohort study

Shim SH, Lim J, Kim JH, Lee YJ, Ha HI, Lim MC, Won YJ

Objective: To evaluate trends in the incidence and survival outcomes of endometrial cancer (EC) based on the year of diagnosis, stage, age, and histologic types. Methods: Women with primary EC diagnosed...
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Efficacy of fertility-sparing treatment with LNG-IUS is associated with different ProMisE subtypes of endometrial carcinoma or atypical endometrial hyperplasia

Lv X, Guo L, Wang C

Objective: To determine whether proactive molecular risk classifier for endometrial cancer (ProMisE) could be used to assess the prognosis of patients with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer...
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Implementation rate and related factors of confirmatory tests following an abnormal Pap smear: a nationwide study from the National Health Insurance

Kim H, Kim KY, Kim D, Hwang JH

Objective: This study aims to investigate the implementation rate and influencing factors of confirmatory tests for women with abnormal cervical cytology results in the Korean nationwide cervical cancer screening program. Methods:...
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Supragastric lesser sac: an insidious site for surgical exploration during the debulking surgery in advanced ovarian cancer

Chen Y, Sun Z, Cai S, Hu Y, Jiang R, Xiang L, Zang R

Objective: Metastases in the supragastric lesser sac (SGLS) are not only occult but are also barriers to complete resection of ovarian cancer. We describe a cohort of patients with SGLS...
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Improved bladder function in radical hysterectomy without worsening oncologic outcome: resection of the posterior layer of the vesicouterine ligament with the procedure limited to the vesical veins

Chikazawa K, Imai K, Kuwata T, Konno R

Objective: The classic Okabayashi nerve-sparing radical hysterectomy involves complete resection of the posterior leaf of the vesicouterine ligament, whereas in the simplified nerve-sparing radical hysterectomy, only the vesical veins and...
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Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan

Lee YY, Lai YL, Kim MS, Chang K, Kim HS, Cheng WF, Chen YL

Objective: In early-stage endometrial cancer, aggressive histologic types (grade 3 endometrioid, serous, clear cell, carcinosarcomas, undifferentiated, mixed, and other unusual types) are associated with an increased risk of distant metastases...
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The automatic diagnosis artificial intelligence system for preoperative magnetic resonance imaging of uterine sarcoma

Toyohara Y, Sone K, Noda K, Yoshida K, Kato S, Kaiume M, Taguchi A, Kurokawa R, Osuga Y

Objective: Magnetic resonance imaging (MRI) is efficient for the diagnosis of preoperative uterine sarcoma; however, misdiagnoses may occur. In this study, we developed a new artificial intelligence (AI) system to...
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