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Pattern of practice for postoperative management of endometrial cancer in Korea: a survey by the Korean Gynecologic Oncology Group and the Korean Radiation Oncology Group (KGOG 2028-KROG 2104)

Lee SU, Kim JY, Kim MK, Kim YS, Kim YJ, Eom KY, Wee CW

Objective This study aimed to investigate the current status of postoperative management of uterine endometrial cancer (EC) in Korea. Methods A mail survey was administered to members of the Korean Gynecologic Oncology Group...
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Reconstruction of the diaphragm with autologous fascia lata during cytoreduction in patients with advanced ovarian cancer

Kanao H, Tsumura S

Cytoreductive surgery for patients with advanced ovarian cancer often requires full-thickness resection of the diaphragm [1]. In most cases, the diaphragm can be closed directly; however, when the defect is...
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Parametrial involvement and decreased survival of women with FIGO stage IIIC1 cervical cancer

Chang H, Wang M, Liu Y, Wu Y

Objective To evaluate the effect of parametrial status on FIGO stage IIIC1 cervical cancer. Methods A retrospective study was conducted from June 1, 2009, to December 31, 2018.Patients with stage IIIC1 cervical cancer...
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RB1 alteration and poor prognosis in women with high-grade neuroendocrine carcinoma of the uterine cervix: a NeCTuR study

Legarreta AF, Salvo G, Gonzales NR, Chisholm G, Hillman RT, Frumovitz M

Objective To describe the gene alteration status in high-grade neuroendocrine cervical carcinoma (NECC) specimens and to explore the potential association of unique gene alterations with survival. Methods Results from tumor-based molecular testing on...
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Adjuvant pelvic radiation versus observation in intermediate-risk early-stage cervical cancer patients following primary radical surgery: a propensity score-adjusted analysis

Tuscharoenporn T, Muangmool T, Charoenkwan K

Objective To compare survival outcomes, posttreatment complications, and quality of life (QoL) of early-stage cervical cancer patients with intermediate-risk factors between those who received adjuvant pelvic radiation and those without adjuvant...
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Effects of a fertility-sparing re-treatment for recurrent atypical endometrial hyperplasia and endometrial cancer: a systematic literature review

Murakami I, Machida H, Morisada T, Terao Y, Tabata T, Mikami M, Hirashima Y, Kobayashi Y, Baba T, Nagase S

Objective To examine the effectiveness of progestin re-treatment for recurrent endometrial intraepithelial neoplasia (EIN), atypical endometrial hyperplasia (AH) and endometrial cancer (EC) following initial fertility-sparing treatment. Methods A comprehensive systematic review and meta-analysis...
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Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis

Su H, Jin Y, Tao C, Yang H, Yang E, Zhang WG, Feng F

Objective We aimed to investigate the differences of transcriptome profile between 2 groups of high-grade serous ovarian cancer (HGSOC) patients with distinct outcomes and identify potential biomarkers for recurrence. Methods RNA sequencing was...
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Effectiveness and safety of nab-paclitaxel and platinum as first-line chemotherapy for ovarian cancer: a retrospective study

Wang L, Li S, Zhu D, Qin Y, Wang X, Hong Z, Han Z

Objective To evaluate the effectiveness and safety of nab-paclitaxel plus platinum as first-line chemotherapy for ovarian cancer (OC). Methods Patients administered platinum combined with nab-paclitaxel as first-line chemotherapy for epithelial OC, fallopian tube...
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Histopathological subtyping of high-grade serous ovarian cancer using whole slide imaging

Miyagawa C, Nakai H, Otani T, Murakami R, Takamura S, Takaya H, Murakami K, Mandai M, Matsumura N

Objective We have established 4 histopathologic subtyping of high-grade serous ovarian cancer (HGSOC) and reported that the mesenchymal transition (MT) type has a worse prognosis than the other subtypes. In this...
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PTEN mutation predicts unfavorable fertility preserving treatment outcome in the young patients with endometrioid endometrial cancer and atypical hyperplasia

Xue Y, Dong Y, Lou Y, Lv Q, Shan W, Wang C, Chen X

Objective This study aimed to investigate the impact of molecular classification and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment in the patients with endometrioid endometrial cancer...
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RAD51/geminin/γH2AX immunohistochemical expression predicts platinum-based chemotherapy response in ovarian high-grade serous carcinoma

Kim K, Kim SH, Lee JY, Kim YN, Lee ST, Park E

Objective The RAD51 assay is a recently developed functional assay for homologous recombination deficiency (HRD) that reflects real-time HRD status. We aimed to identify the applicability and predictive value of RAD51...
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