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A carrier as a gynecologic oncologist in an academic hospital in a developing country

Nugroho H

Being a gynecologic oncologist in an academic hospital in a developing country can be challenging. Problems that exist include the high number of patients, where most of the cases are...
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Single-cell transcriptomics reveals tissue architecture in ovarian carcinosarcoma

Xu J, Lu W

Objective Ovarian carcinosarcoma (OCS) is one of rarest and most challenging histologic subtype of ovarian cancer. It features remarkable cellular heterogeneity. Using single-cell RNA sequencing (scRNA-seq), we characterize the cellular composition...
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Epithelial-mesenchymal transition in fertility sparing management of endometrial cancer: report of two cases

Yang J, Yang J, Xiang Y

Endometrial cancer (EC) is the most common gynecologic malignancy. A significant number of patients are diagnosed during reproductive age in nowadays. The importance of fertility preservation for EC has become...
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Psychosocial burden in women with positive human papillomavirus testing after abnormal cervical cytology: atypical squamous cells of undetermined significance (ASC-US)

Chittithaworn S, Suphattanaporn O, Kongsawatvorakul C, Paiwattananupant K

Objective To evaluate the psychosocial burden in the woman with positive human papillomavirus (HPV) testing following abnormal cervical cytology: atypical squamous cells of undetermined significance (ASC-US). Methods This prospective cross-sectional study includes Thai...
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A case of isolated inguinal nodal cancer of Mullerian origin

Wong J, Tong P

Inguinal nodal disease has been reported to be a rare metastatic site for cancer of Mullerian origin. However, isolated inguinal nodal disease has not been reported in literature. We report...
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Oncological and reproductive outcomes after fertility-sparing surgery in patients with seromucinous borderline ovarian tumor: results of a large retrospective study

Wang D, Jia S, Jia C, Cao D, Yang J, Yang J, Xiang Y

Objective To evaluate the oncological and reproductive outcomes in patients with seromucinous borderline ovarian tumors (SMBOT) treated with fertility-sparing surgery (FSS). Methods We retrospectively reviewed the medical records of patients with SMBOT who...
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Exploiting DNA replication stress for sequential therapy with PARP and WEE1 inhibitors

Fang Y

We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly tolerated. Concurrent treatment with PARP and WEE1 inhibitors induces replication...
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Real-world outcomes of niraparib treatment in patients with ovarian cancer: the first observational multicenter study in China

Li J, Yang J, Shou H, Zhang L, Huang X, Tang X, Zheng F, Liu F, Wu X

Objective The objective of this study was to present the real-world patients’ portrait, and the results of niraparib treatment in China. Methods This study included 142 patients treated with niraparib from 8 hospitals...
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A prospective multicenter cohort study comparing vNOTES and laparoscopic sentinel lymph node mapping for endometrial cancer

Deng L, Chen K, Deng Y, Tang S, Sun L, Wang Y

Objective To determine the feasibility and safety of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) in hysterectomy and sentinel lymph node (SLN) mapping for endometrial cancer by comparing its SLN detection...
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The randomized controlled trial on the efficacy of surgical debulking of metastatic lymph nodes in cervical cancer stage IIICr

He M, Zou D

The management of patients with bulky positive lymph nodes who may not candidates for radical surgery and not response to concurrent chemoradiotherapy (CCRT) has unmet clinical need for years. Surgical...
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Novel therapeutic approach for uterine leiomyosarcoma based on transcriptome analysis

Yoshida K, Yokoi A, Kato T, Kajiyama H

Uterine leiomyosarcoma (ULMS) is one of the most aggressive gynecological malignancies. In the past decade, novel therapeutic agents such as trabectedin and pazopanib have been approved, but the prognosis of...
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The acceptability of vaginal self-sampling for human papillomavirus (HPV) testing among a multi-ethnic Asian female population

Gunasagran Y, Khoo SP, Yam ML, Woo YL

Objective In Malaysia, a cytology based program for cervical screening was implemented in 1969. Unfortunately, pap smear uptake has been low. The most common barriers to screening were embarrassment, time constraint...
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Efficacy and impact of PARPi monotherapy to subsequent platinum-based chemotherapy in BRCA1/2 mutant ovarian cancer patients with secondary platinum-sensitive relapse

Kun S, Ma Y, Bu H, Kong B

Objective The therapeutic effect of poly(ADP-ribose) polymerase inhibitors (PARPi) monotherapy compared with platinum-based chemotherapy, and the impact to subsequent platinum-based chemotherapy after PARPi resistance were inconclusive. Methods BRCA1/2 mutant ovarian cancer patients with...
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Significance of TCGA molecular classification in fertility-sparing treatment of endometrial cancer and atypical hyperplasia

Yiqin W, Nan K, Liwei L, Zhiqi W, Rong Z, Danhua S, Jianliu W

Objective To investigate The Cancer Genome Atlas (TCGA) molecular classification of endometrial cancer (EC) and endometrial atypical hyperplasia (AH) treated with fertility-sparing therapy. Methods A total of 46 EC and AH patients who...
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Diagnostic performance of magnetic resonance imaging (MRI) in patients with operable cervical cancer: a retrospective analysis

Kulkarni R, Thakkar J, Thakur M, Deodhar K, Poddar P, Maheshwari A

Objective Magnetic resonance imaging (MRI) has become an integral part of pre-operative work up of patients with early cervical cancer. It has superior soft tissue delineation and therefore useful in evaluation...
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