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Surviving the COVID-19 pandemic: early response of a gynecologic oncology unit in Singapore

Lim YH, Chay WY, Wong WL

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Comments on: Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: a Gynecologic Cancer Inter-Group (GCIG) study

Park JY

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Olaparib and bevacizumab in frontline maintenance of ovarian cancer: an over reliance in unpowered subgroup analysis of the PAOLA-1 trial?

Paulino E, Melo ACd

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Uterine clear cell carcinoma risk in White versus non-White US subpopulations: does race matter?

Chow S, Wong D, Liao CI, Mann A, Tian C, Darcy KM, Chan JK

Objective: To determine incidence rates of uterine clear cell carcinoma among non-White US subpopulations. Methods: Data from the United States Cancer Statistics and National Cancer Database from 2004 to 2016 were...
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Evaluation of the optimal sequence of adjuvant chemotherapy and radiation therapy in the treatment of advanced endometrial cancer

McEachron J, Zhou N, Spencer C, Shanahan L, Chatterton C, Singhal P, Lee YC

Objective: The optimal sequence of adjuvant chemoradiation in the treatment of advanced endometrial carcinoma (EC) remains unclear. We sought to evaluate the outcomes of patients treated with chemoradiation in sandwich...
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Impact of COVID-19 in gynecologic oncology: a Nationwide Italian Survey of the SIGO and MITO groups

Bogani G, Apolone G, Ditto A, Scambia G, Panici PB, Angioli R, Pignata S, Greggi S, Scollo P, Delia M, Franchi M, Martinelli F, Signorelli M, Lopez S, Donato VD, Valabrega G, Ferrandina G, Palaia I, Bergamini A, Bocciolone L, Savarese A, Ghezzi F, Casarin J, Pinelli C, Trojano V, Chiantera V, Giorda G, Sopracordevole F, Malzoni M, Salerno G, Sartori E, Testa A, Zannoni G, Zullo F, Vizza E, Trojano G, Chiantera A, Raspagliesi F

Objective: Coronavirus disease 2019 (COVID-19) has caused rapid and drastic changes in cancer management. The Italian Society of Gynecology and Obstetrics (SIGO), and the Multicenter Italian Trials in Ovarian cancer...
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Management of stage II endometrial cancer and subsequent oncologic outcomes: a National Cancer Database study

Vetter MH, Bixel K, Felix AS

Objective: The management of stage II endometrial cancer (EC) is challenging due to the wide variation in surgical practice and adjuvant treatment recommendations. We sought to describe the treatment patterns...
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Reclassification of BRCA1 and BRCA2 variants found in ovarian epithelial, fallopian tube, and primary peritoneal cancers

Ha HI, Ryu JS, Shim H, Kong SY, Lim MC

Objective: We investigated the proportions of and reclassified BRCA1/2 variants of unknown significance (VUS) in Korean patients with epithelial ovarian, tubal, and primary peritoneal cancers. Methods: Data from 805 patients who...
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High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo

Ikeda Y, Sato S, Yabuno A, Shintani D, Ogasawara A, Miwa M, Zewde M, Miyamoto T, Fujiwara K, Nakamura Y, Hasegawa K

Objective: Maternal embryonic leucine zipper kinase (MELK) is receiving an attention as a therapeutic target in various types of cancers. In this study, we aimed to evaluate the prognostic significance...
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Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer

Chang JS, Kim N, Kim JY, Do SI, Cho Y, Kim HS, Kim YB

Objective: Kallikrein 5 (KLK5), which is frequently observed in normal cervico-vaginal fluid, is known to be related to prognosis in several solid tumors. We investigated the prognostic significance of KLK5...
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Feasibility and safety of fertilitysparing surgery in epithelial ovarian cancer with dense adhesion: a longterm result from a single institution

Baek MH, Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT

Objective: We investigated the feasibility and safety of fertility-sparing surgery (FSS) in patients with epithelial ovarian cancer (EOC) with dense adhesions. Methods: Patients were divided into cases with and without dense...
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Surgical or imaging lymph node assessment in locally advanced cervical cancer: a systematic review and meta-analysis

Delara R, Yang J, Buckner-Petty S, Magtibay P, Butler K

Objective: To evaluate the survival impact of imaging vs surgical nodal assessment in patients with cervical cancer stage IB2–IVA prior to definitive chemoradiotherapy (CRT). Methods: PubMed, MEDLINE, Cochrane Library, and ClinicalTrials.gov...
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Does adenocarcinoma have a worse prognosis than squamous cell carcinoma in patients with cervical cancer? A real-world study with a propensity score matching analysis

Pan X, Yang W, Wen Z, Li F, Tong L, Tang W

Objective: To compare survival outcomes between cervical adenocarcinoma (ADC) and squamous cell carcinoma (SCC) using a propensity score matching (PSM) analysis based on the Surveillance, Epidemiology, and End Results (SEER)...
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High mobility group box 3 promotes cervical cancer proliferation by regulating Wnt/β-catenin pathway

Zhuang S, Yu X, Lu M, Li Y, Ding N, Ding Y

Objective: High mobility group box 3 (HMGB3) plays an important role in the development of various cancer. This study aims to explore whether HMGB3 regulates cervical cancer (CC) progression and...
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The post-progression survival of patients with recurrent or persistent ovarian clear cell carcinoma: results from a randomized phase III study in JGOG3017/GCIG

Kondo E, Tabata T, Suzuki N, Aoki D, Yahata H, Kotera Y, Tokuyama O, Fujiwara K, Kimura E, Terauchi F, Sumi T, Okamoto A, Yaegashi N, Enomoto T, Sugiyama T

Objective: In this study we sought to investigate the clinical factors that affect postprogression survival (PPS) in patients with recurrent or persistent clear cell carcinoma (CCC). We utilized the JGOG3017/Gynecological Cancer...
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