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Update on immune checkpoint inhibitors in gynecological cancers

Heong V, Ngoi N, Tan DS

In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy...
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Clinical statistics of gynecologic cancers in Japan

Yamagami W, Nagase S, Takahashi , Ino K, Hachisuga , Aoki D, Katabuchi

Cervical, endometrial, and ovarian cancers, have both high morbidity and mortality among the gynecologic malignant tumors in Japan. The present study was conducted using both the population-based cancer registry and...
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Development of the short version of the Gynecologic Cancer Lymphedema Questionnaire: GCLQ-7

Kim SI, Kim N, Lee S, Lee S, Joo J, Seo SS, Chung SH, Park SY, Lim MC

OBJECTIVE: The Gynecologic Cancer Lymphedema Questionnaire (GCLQ) was designed to identify gynecologic cancer patients with lower limb lymphedema (LLL). The questionnaire consists of 20 items distributed over 7 symptom clusters....
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Computed tomography-based quantitative assessment of lower extremity lymphedema following treatment for gynecologic cancer

Yoo JS, Chung SH, Lim MC, Kim YJ, Kim KG, Hwang JH, Kim YH

OBJECTIVE: To develop an algorithmic quantitative skin and subcutaneous tissue volume measurement protocol for lower extremity lymphedema (LEL) patients using computed tomography (CT), to verify the usefulness of the measurement...
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Comparing and evaluating the efficacy of methotrexate and actinomycin D as first-line single chemotherapy agents in low risk gestational trophoblastic disease

Lee YJ, Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH

OBJECTIVE: The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy...
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Preoperative CA125 and fibrinogen in patients with endometrial cancer: a risk model for predicting lymphovascular space invasion

Zhou X, Wang H, Wang X

OBJECTIVE: The aim of this study was to build a model to predict the risk of lymphovascular space invasion (LVSI) in women with endometrial cancer (EC). METHODS: From December 2010 to...
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Impact of histological subtype on survival in patients with locally advanced cervical cancer that were treated with definitive radiotherapy: adenocarcinoma/adenosquamous carcinoma versus squamous cell carcinoma

Yokoi E, Mabuchi S, Takahashi , Matsumoto , Kuroda H, Kozasa K, Kimura T

OBJECTIVE: To compare the survival outcomes of patients with cervical squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) among patients with locally advanced cervical cancer that were treated with definitive...
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Feature of amenorrhea in postoperative tamoxifen users with breast cancer

Kim H, Han W, Ku SY, Suh CS, Kim SH, Choi YM

OBJECTIVE: Tamoxifen has been used to prevent the recurrence of breast cancer. However, tamoxifen-users frequently experience amenorrhea and it can be confused from that caused by other hormonal abnormalities. In...
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The detection of sentinel lymph nodes in laparoscopic surgery for uterine cervical cancer using 99m-technetium-tin colloid, indocyanine green, and blue dye

Tanaka T, Terai Y, Ashihara K, Tsunetoh S, Akagi H, Yamada T, Ohmichi M

OBJECTIVE: Our objective was to determine the feasibility and detection rates and clarify the most effective combination of injected tracer types for sentinel lymph node (SLN) mapping in uterine cervical...
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Salinomycin reduces stemness and induces apoptosis on human ovarian cancer stem cell

Lee HG, Shin SJ, Chung HW, Kwon SH, Cha SD, Lee JE, Cho CH

OBJECTIVE: Cancer stem cells (CSCs) represent a subpopulation of undifferentiated tumorigenic cells thought to be responsible for tumor initiation, maintenance, drug resistance, and metastasis. The role of CSCs in drug...
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