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Atypical Anterior Spinal Artery Infarction due to Left Vertebral Artery Occlusion Presenting with Bilateral Hand Weakness

Kim MJ, Jang MH, Choi MS, Kang SY, Kim JY, Kwon KH, Kang IW, Cho SJ

BACKGROUND: Infarct of the anterior spinal artery is the most common subtype of spinal cord infarct, and is characterized by bilateral motor deficits with spinothalamic sensory deficits. We experienced a...
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Involvement of Peripheral and Central Nervous Systems in a Valosin-Containing Protein Mutation

Segers K, Glibert G, Callebaut , Kevers L, Alcan I, Dachy B

BACKGROUND: Inclusion-body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD) is a rare, late-onset autosomal disorder arising from missense mutations in a gene coding for valosin-containing protein. CASE...
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Ocular Dipping in Creutzfeldt-Jakob Disease

Sierra-Hidalgo F, Llamas S, Gonzalo JF, Sanchez Sanchez C

BACKGROUND: Ocular dipping (OD), or inverse ocular bobbing, consists of slow, spontaneous downward eye movements with rapid return to the primary position. It has been mainly reported following hypoxic-ischemic encephalopathy,...
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Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Korea: Clinical Features, Treatment, and Outcome

Lim JA, Lee ST, Jung KH, Kim S, Shin JW, Moon J, Byun JI, Kim TJ, Shin YW, Lee KJ, Kim YS, Park KI, Lee SK, Chu K

BACKGROUND AND PURPOSE: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune synaptic encephalitis and it often responds to treatment. We analyzed the clinical characteristics of anti-NMDAR encephalitis...
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Validity of Korean Versions of the Multiple Sclerosis Impact Scale and the Multiple Sclerosis International Quality of Life Questionnaire

Huh SY, Joo J, Kim SH, Joung AR, Park K, Kim W, Park MS, Kim HJ

BACKGROUND AND PURPOSE: Assessment of the health-related quality of life (HRQoL) is important in clinical evaluations of multiple sclerosis (MS) patients for quantifying the impact of illness and treatment on...
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Antioxidant Effects of Statins in Patients with Atherosclerotic Cerebrovascular Disease

Moon GJ, Kim SJ, Cho YH, Ryoo S, Bang OY

BACKGROUND AND PURPOSE: Oxidative stress is involved in the pathophysiological mechanisms of stroke (e.g., atherosclerosis) and brain injury after ischemic stroke. Statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, have...
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Association between Ischemic Stroke and Vascular Shear Stress in the Carotid Artery

Jeong SK, Lee JY, Rosenson R

BACKGROUND AND PURPOSE: Vascular shear stress is essential for maintaining the morphology and function of endothelial cells. We hypothesized that shear stress in the internal carotid artery (ICA) may differ...
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Obsessive-Compulsive Symptoms and Their Impacts on Psychosocial Functioning in People with Epilepsy

Seo JH, Lee WK, Park SP

BACKGROUND AND PURPOSE: Obsessive-compulsive symptoms (OCS) in people with epilepsy (PWE) have not been studied systematically. We evaluated the severity, predictors, and psychosocial impact of OCS in PWE. METHODS: We recruited...
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Clinical and Electrophysiologic Responses to Acetylcholinesterase Inhibitors in MuSK-Antibody-Positive Myasthenia Gravis: Evidence for Cholinergic Neuromuscular Hyperactivity

Shin HY, Park HJ, Lee HE, Choi YC, Kim SM

BACKGROUND AND PURPOSE: Patients with muscle-specific tyrosine kinase (MuSK) antibody (MuSK-Ab)-positive myasthenia gravis (MG) show distinct responses to acetylcholinesterase inhibitors (AChEIs). Although clinical responses to AChEIs in MuSK-Ab MG are...
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Idiopathic Small Fiber Neuropathy: Phenotype, Etiologies, and the Search for Fabry Disease

Samuelsson K, Kostulas K, Vrethem M, Rolfs A, Press R

BACKGROUND AND PURPOSE: The etiology of small fiber neuropathy (SFN) often remains unclear. Since SFN may be the only symptom of late-onset Fabry disease, it may be underdiagnosed in patients...
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Long-Term Outcomes of Hemispheric Disconnection in Pediatric Patients with Intractable Epilepsy

Lee YJ, Kim EH, Yum MS, Lee JK, Hong S, Ko TS

BACKGROUND AND PURPOSE: Hemispherectomy reportedly produces remarkable results in terms of seizure outcome and quality of life for medically intractable hemispheric epilepsy in children. We reviewed the neuroradiologic findings, pathologic...
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Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study

Kim JK, Bae JS, Kim DS, Kusunoki S, Kim JE, Kim JS, Park YE, Park KJ, Song HS, Kim SY, Lim JG, Kim NH, Suh BC, Nam TS, Park MS, Choi YC, Sohn EH, Na SJ, Huh SY, Kwon O, Lee SY, Lee SH, Oh SY, Jeong SH, Lee TK, Kim DU

BACKGROUND AND PURPOSE: No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was...
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Analysis of Spatial and Temporal Protein Expression in the Cerebral Cortex after Ischemia-Reperfusion Injury

Chen YH, Chiang YH, Ma HI

BACKGROUND AND PURPOSE: Hypoxia, or ischemia, is a common cause of neurological deficits in the elderly. This study elucidated the mechanisms underlying ischemia-induced brain injury that results in neurological sequelae. METHODS:...
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Why Is It Difficult to Predict Language Impairment and Outcome in Patients with Aphasia after Stroke?

Charidimou A, Kasselimis D, Varkanitsa M, Selai C, Potagas C, Evdokimidis I

One of the most devastating consequences of stroke is aphasia. Communication problems after stroke can severely impair the patient's quality of life and make even simple everyday tasks challenging. Despite...
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