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Cerebral Infarction Producing Sudden Isolated Foot Drop

Ku BD, Lee EJ, Kim H

Foot drop usually results from lesions affecting the peripheral neural pathway related to dorsiflexor muscles, especially the peroneal nerve. Although a central nervous system lesion is suspected when there is...
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Reversible Verbal and Visual Memory Deficits after Left Retrosplenial Infarction

Kim JH, Park KY, Seo SW, Na DL, Chung CS, Lee KH, Kim GM

The retrosplenial cortex is a cytoarchitecturally distinct brain structure located in the posterior cingulate gyrus and bordering the splenium, precuneus, and calcarine fissure. Functional imaging suggests that the retrosplenium is...
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Striopallidodentate Calcification and Progressive Supranuclear Palsy-Like Phenotype in a Patient with Idiopathic Hypoparathyroidism

Kim TW, Park IS, Kim SH, Lee KS, Kim YI, Kim JS

We present a 77-year-old woman with levodopa-nonresponsive parkinsonism, dementia, and supranuclear gaze palsy on vertical and horizontal gaze. Laboratory findings were consistent with idiopathic hypoparathyroidism, and brain computed tomography showed...
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Mild Encephalopathy with Reversible Lesion in the Splenium of the Corpus Callosum and Bilateral Frontal White Matter

Cho JS, Ha SW, Han YS, Park SE, Hong KM, Han JH, Cho EK, Kim DE, Kim JG

A 59-year-old man visited an emergency room due to the sudden onset of severe dysarthria with a drowsy mental status. MRI demonstrated T2 prolongation and restricted diffusion involving the splenium...
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Two Cases of Hypertensive Encephalopathy Involving the Brainstem

Kang SY, Choi JC, Kang JH

Hypertensive encephalopathy is a medical emergency whose clinical manifestations are usually associated with bilateral parieto-occipital lesions. Predominant brainstem edema without accompanying occipital lesions is rare in hypertensive encephalopathy and usually...
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Rapidly Progressive Toxic Leukoencephalomyelopathy with Myelodysplastic Syndrome: a Clinicopathological Correlation

Jung KH, Chu K, Kim YA, Jeon BS

Neurological disorders induced by long-term exposure to organic solvents typically have a slowly progressive clinical course, which may be arrested or even reversed following discontinuation of exposure. We report an...
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Anticipation and Phenotypic Heterogeneity in Korean Familial Amyotrophic Lateral Sclerosis with Superoxide Dismutase 1 Gene Mutation

Kim W, Kim JS, Lee KS, Gwoun YJ, Kim JM, Lee KH

BACKGROUND AND PURPOSE: Different mutations in the Cu/Zn superoxide dismutase 1 (SOD1) gene have been reported in approximately 10% of cases of familial amyotrophic lateral sclerosis (ALS). The aim of...
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Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients

Seo JG, Lee DI, Hwang YH, Lee HW, Jung DK, Suh CK, Kwon SH, Park SP

BACKGROUND AND PURPOSE: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients. METHODS: This retrospective study investigated 60 epilepsy patients...
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Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura

Park JW, Lee KS, Kim JS, Kim YI, Shin HE

BACKGROUND: Recent genetic association studies have investigated the possible genetic role of the dopaminergic system in migraine. Catechol-O-methyltransferase (COMT) is an enzyme that plays a crucial role in the metabolism...
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Decreased Vasomotor Reactivity in Alzheimer's Disease

Lee ST, Jung KH, Lee YS

BACKGROUND: Reduced cerebral blood flow and microvascular abnormalities have been suggested as the vascular pathogenesis of Alzheimer's disease (AD). Transcranial Doppler sonography (TCD) can be used as a noninvasive method...
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Cognitive Dysfunction in 16 Patients with Carotid Stenosis: Detailed Neuropsychological Findings

Kim JE, Lee BR, Chun JE, Lee SJ, Lee BH, Yu IK, Kim S

BACKGROUND: Impairment of cognitive function is often present in patients with carotid artery stenosis but the details of this dysfunction have rarely been reported. Our purpose was to elucidate the...
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Ultrasound Enhanced Thrombolysis: Applications in Acute Cerebral Ischemia

Tsivgoulis G, Alexandrov AV

Intravenous tissue plasminogen activator (TPA) improves patient chances to recover from stroke by inducing mostly partial recanalization of large intracranial thrombi. TPA activity can be enhanced with ultrasound including 2...
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