- Astrocytes, Microglia, and Parkinson's Disease
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Joe EH, Choi DJ, An J, Eun JH, Jou I, Park S
- KMID: 2410468
- Exp Neurobiol.
- 2018 Apr;27(2):77-87.
- doi: 10.5607/en.2018.27.2.77
Astrocytes and microglia support well-being and well-function of the brain through diverse functions in both intact and injured brain. For example, astrocytes maintain homeostasis of microenvironment of the brain through... -
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- Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra
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Jeong HK, Jou I, Joe EH
- KMID: 1115266
- Exp Mol Med.
- 2010 Dec;42(12):823-832.
- doi: 10.3858/emm.2010.42.12.085
It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged... -
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- Absence of Delayed Neuronal Death in ATP-Injected Brain: Possible Roles of Astrogliosis
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Jeong HK, Jou I, Joe EH
- KMID: 2284634
- Exp Neurobiol.
- 2013 Dec;22(4):308-314.
- doi: 10.5607/en.2013.22.4.308
Although secondary delayed neuronal death has been considered as a therapeutic target to minimize brain damage induced by several injuries, delayed neuronal death does not occur always. In this study,... -
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- Kir4.1 is coexpressed with stemness markers in activated astrocytes in the injured brain and a Kir4.1 inhibitor BaCl 2 negatively regulates neurosphere formation in culture
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Kwon JK, Choi DJ, Yang H, Ko DW, Jou I, Park SM, Joe EH
- KMID: 2521482
- Korean J Physiol Pharmacol.
- 2021 Nov;25(6):565-574.
- doi: 10.4196/kjpp.2021.25.6.565
Astrocytes are activated in response to brain damage. Here, we found that expression of Kir4.1, a major potassium channel in astrocytes, is increased in activated astrocytes in the injured brain... -
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- Brain Inflammation and Microglia: Facts and Misconceptions
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Jeong HK, Ji K, Min K, Joe EH
- KMID: 1427103
- Exp Neurobiol.
- 2013 Jun;22(2):59-67.
- doi: 10.5607/en.2013.22.2.59
The inflammation that accompanies acute injury has dual functions: bactericidal action and repair. Bactericidal functions protect damaged tissue from infection, and repair functions are initiated to aid in the recovery... -
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- Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases
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Woo JH, Lee JH, Kim H, Park SJ, Joe EH, Jou I
- KMID: 2165543
- Exp Neurobiol.
- 2015 Jun;24(2):95-102.
- doi: 10.5607/en.2015.24.2.95
The term 'inflammation' was first introduced by Celsus almost 2000 years ago. Biological and medical researchers have shown increasing interest in inflammation over the past few decades, in part due... -
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- Suppression of miR-155 Expression in IFN-gamma-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression
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Kim JH, Jou I, Joe EH
- KMID: 2165515
- Exp Neurobiol.
- 2014 Jun;23(2):148-154.
- doi: 10.5607/en.2014.23.2.148
Previously, we reported that DJ-1, encoded by a Parkinson's disease (PD)-associated gene, inhibits expression of proinflammatory mediators in interferon-gamma (IFN-gamma)-treated astrocytes and microglia through inhibition of STAT1 activation. Here, using... -
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- Protein kinase A mediates microglial activation induced by plasminogen and gangliosides
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Min KJ, Yang MS, Jou I, Joe EH
- KMID: 1123767
- Exp Mol Med.
- 2004 Oct;36(5):461-467.
In the injured brain, microglia is known to be activated and produce proinflammatory mediators such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS). We investigated... -
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- PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation
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Choi I, Woo JH, Jou I, Joe EH
- KMID: 2165574
- Exp Neurobiol.
- 2016 Feb;25(1):14-23.
- doi: 10.5607/en.2016.25.1.14
PTEN-induced putative kinase 1 (PINK1) is a Parkinson's disease (PD) gene. We examined miRNAs regulated by PINK1 during brain development and neural stem cell (NSC) differentiation, and found that lvels... -
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- LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
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Choi I, Byun JW, Park SM, Jou I, Joe EH
- KMID: 2354880
- Exp Neurobiol.
- 2016 Oct;25(5):269-276.
- doi: 10.5607/en.2016.25.5.269
Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474... -
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- Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake
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Lee JS, Hong JM, Yoon BS, Son KS, Lee KE, Im DS, Park BN, An YS, Hwang DH, Park CB, Kim BG, Joe Eh
- KMID: 2500519
- Exp Neurobiol.
- 2020 Feb;29(1):70-79.
- doi: 10.5607/en.2020.29.1.70
Many previous studies have shown reduced glucose uptake in the ischemic brain. In contrast, in a permanent unilateral common carotid artery occlusion (UCCAO) mouse model, our pilot experiments using 18F-fluorodeoxyglucose... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses
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Lee SY, Kim B, Yoon S, Kim YJ, Liu T, Woo JH, Chwae YJ, Joe EH, Jou I
- KMID: 983958
- Exp Mol Med.
- 2010 Sep;42(9):662-673.
- doi: 10.3858/emm.2010.42.9.066
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5Kalpha) that is responsible for... -
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