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Tumor Necrosis Rate to Peak Serum Level of MTX in the Preoperative Chemotherapy of Osteosarcoma

Son JW, Kim JD, Jung SH, Jaug JH, Lee SM, Kim C, Cha JS

  • KMID: 2399038
  • J Korean Orthop Assoc.
  • 2003 Aug;38(4):372-377.
PURPOSE: High dose methotrexate (HDMTX) dramatically increases survival rate, which is related to the histologic response of tumornecrosis rate in the treatment of osteosarcoma. But, the study of tumor necrosis...
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